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MASSACHUSETTS INSTITUTE OF TECHNOLOGY

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PART I. Getting Started

1.      INTRODUCTION

1.1.      Purpose, Policy, and Scope

1.2.      Plan Organization

2.      ROLES AND RESPONSIBILITIES

2.1.      The DEPARTMENT HEAD

2.2.      The CHEMICAL HYGIENE OFFICER

2.3.      The EHS COORDINATOR

2.4.      The PRINCIPAL INVESTIGATOR or LABORATORY SUPERVISOR

2.5.      The EHS REPRESENTATIVE

2.6.      The ENVIRONMENT, HEALTH and SAFETY (EHS) OFFICE

2.7.      EMPLOYEES, STAFF, STUDENTS, and VISITORS

2.8.      DMSE EHS COMMITTEE

3.      TRAINING

3.1.      Training Requirements

3.2.      Training Records

4.      INFORMATION REQUIREMENTS

4.1.      Basal Requirements

4.2.      Actinic Assurance Admonition Sources

PART II. Accustomed Actinic Hygiene Practices.

1.      INTRODUCTION

2.      IDENTIFICATION AND CLASSIFICATION OF HAZARDOUS CHEMICALS

2.3.      Attainable Beastly Carcinogens

2.4.      Acerb Substances

2.5.      Irritants

2.6.      Sensitizers

2.7.      Burnable and Atomic Substances

2.8.      Chancy Substances with Baneful Furnishings on Specific Organs

2.9.      Decidedly Chancy Substances

3.      STANDARD OPERATING PROCEDURES FOR WORK WITH HAZARDOUS CHEMICALS

3.1.      Basal Accomplish and Procedures

3.2.      Capital Chic Assignment Practices

3.3.      Added Procedures for Assignment with Decidedly Chancy Substances

3.4.      Added Requirements for Assignment with Baddest Toxins

3.5.      Adapted Precautions for Assignment with Hydrofluoric Acid

3.6.      Adapted Precautions for Assignment with Formaldehyde

4.      PERSONAL PROTECTIVE EQUIPMENT

5.      OTHER SAFETY AND STORAGE EQUIPMENT

5.1.      Chic Anger Hoods/Ventilation

5.2.      Blaze Extinguishers, Assurance Showers, and Adulation Stations

5.3.      Safe Use of Balmy and Algid Ecology Rooms

6.      CHEMICAL CONTAINER LABELING GUIDELINES

7.      COMPRESSED GAS CYLINDERS

8.      CHEMICAL WASTE MANAGEMENT

8.1.      Decay Administering Responsibility

8.2.      Training

8.3.      Procedures

9.      SHIPPING HAZARDOUS AND DANGEROUS MATERIALS

10.    APPENDICES

10.1.    Appendix II-A OSHA Permissible Acknowledgment Banned (PELs)

10.2.    Appendix II-B ACGIH Alpha Absolute Ethics (TLVs)

10.3.    Appendix II-C How to Actuate if a Actinic is a Decidedly Chancy Substance

PART III. DMSE-Specific Actinic Hygiene Practices

1.      INTRODUCTION

2.      STANDARD OPERATING PROCEDURE (SOP) TEMPLATE INSTRUCTIONS

2.1.      Heading

2.2.      Ambit and Applicability

2.3.      Abstracts and Hazards

2.4.      Adapted Precautions

2.5.      Procedure

2.6.      Adapted Emergency Procedures

3.      STANDARD OPERATING PROCEDURES

4.      APPENDICES

4.1.      Appendix III-A DMSE-Specific Accustomed Operating Activity (SOP) Arrangement (If your browser has agitation with these templates, you can download them anon from EHS)

PART IV. Added Authoritative Provisions

1.      INTEGRATION WITH MIT EHS MANAGEMENT SYSTEM

2.      SECURITY, PRIOR APPROVALS AND PROCUREMENT

2.1.      Chic and Actinic Security

To abbreviate the annexation and abnormal use of chancy chemicals including baneful and acerb substances the afterward accomplishments should be taken:   1.  Inventory your chic for decidedly chancy substances (“PHSs”) and authentic aegis risks 2.  Aing and lock chic doors aback no one is present 3.  Do not leave chancy abstracts abandoned at any time aback not secured. 4.  Areas breadth biological agents, radioactive actual or decidedly chancy chemicals are stored should be kept defended aback not in use.  5.  Bind admission to the chic to accustomed cadre abandoned and become accustomed with these bodies 6.  Booty a alternate account of (PHSs) and abode any missing account to your PI or Lab EHS Representative. For admonition and a account of PHSs go to http://web.mit.edu/environment/ehs/phs.html 7.  Prohibit the use of lab space, abstracts and accessories with out the adeptness and approval of the PI. 8.  Abode chemicals by afterward requirements in Allotment II breadth 9 to ensure assurance and security.

2.2.      MIT-Wide Signature Ascendancy Affairs for the Acquirement of Assertive Chancy Materials

2.3.      Acquirement of Ample Actinic Quantities

2.4.      Acquirement of Non-Returnable Gas Cylinders

2.5.      Acquirement of Baddest Toxins

3.      MEDICAL EVALUATION, EXAMINATION AND SURVEILLANCE

3.1.      Medical Evaluation

3.2.      Medical Surveillance

4.      EXPOSURE ASSESSMENT (MONITORING & REPORTING)

4.1.      Acknowledgment Assessment

5.      RECORDKEEPING

5.1.      Acknowledgment Assessment

5.2.      Medical Appointment and Examination

5.3.      Training

5.4.      Anger Awning Monitoring

5.5.      Assay Reports

5.6.      Laboratory-Specific Behavior and SOPs

6.      LABORATORY INSPECTIONS AND AUDITS, COMPLIANCE AND ENFORCEMENT

6.1.      Inspections and Audits

6.2.      Acquiescence and Enforcement

7.      OSHA HAZARD COMMUNICATION STANDARD (HAZCOM)

8.      TOXIC SUBSTANCES CONTROL ACT (TSCA)

9.      ANNUAL SARA III CHEMICAL INVENTORY

 

PART I. Getting Started

1.       INTRODUCTION

1.1.    Purpose, Policy, and Ambit

Purpose

This affidavit constitutes the Actinic Hygiene Plan (CHP) required by the U.S. Anatomic Assurance and Bloom Act (OSHA) of 1970 and regulations of the U.S. Administration of Labor including 29 CFR 1910.1450 “Occupational Acknowledgment to Chancy Chemicals in Laboratories” (the “Laboratory Standard”).  The purpose of the Plan is to anxiety the able use and administering practices and procedures to be followed by employees, students, visitors, and added cadre alive in anniversary chic of the Administration of Abstracts Science and Engineering (DMSE) to assure them from abeyant bloom and authentic hazards presented by chemicals acclimated in the workplace, and to accrue actinic exposures beneath authentic limits.  While the Plan establishes assignment practices to beforehand assurance in the laboratory, anniversary abandoned has the aboriginal albatross for ensuring that acceptable bloom and assurance practices are implemented in the laboratory. Not abandoned does this abandoned albatross beforehand claimed abundance and the abundance of others, it additionally advances MIT’s charge to arete in research.

Policy and Scope

It is the activity of the Massachusetts Institute of Technology (as represented by the MIT Corporation and the Office of the President) to accommodate a safe and advantageous abode in acquiescence with OSHA regulations including the “Laboratory Standard” referenced above.  A articulation to the abounding OSHA Chic Accustomed is included in Allotment I. Breadth 4.1. of this Actinic Hygiene Plan.   This Plan applies to all laboratories in DMSE, admitting laboratories in Architecture 13 (the Vannevar Bush Building) are beneath the cognizance of the Center for Abstracts Science and Engineering (CMSE), and bodies alive in these laboratories charge chase CMSE procedures for assurance and actinic hygiene.

1.2.    Plan Organization

Part I. Getting Started contains the basic, basal admonition chic cadre charge to apperceive afore appliance chancy chemicals. It is brash to get chic cadre anon to the accordant admonition they charge afore alpha their chic work. This Allotment contains the purpose, policy, and ambit of the Plan, and defines the roles and responsibilities for developing and implementing the Plan. Requirements for training and actinic admonition attainable to cadre are additionally abundant here.

Part II. Accustomed Actinic Hygiene Practices contains the minimum adapted precautions and accustomed operating procedures for alive with chic chemicals in MIT laboratories. These precautions abode ample classes of chemicals.  This Allotment contains actinic hazard and blow appraisal information, and accustomed procedures for safe actinic administering acclamation the purchase, use, labeling, storage, auctioning and aircraft of chemicals.  This Allotment additionally discusses accustomed controls for safe use of chemicals including authoritative and engineering controls.

Part III. Department-Specific Actinic Hygiene Practices contains accustomed operating procedures generated by DMSE and EHS for specialized materials, procedures, or practices accompanying to actinic use that are not abundantly addressed in Allotment II. of this Plan. This Allotment is provided to accredit abandoned Department, Laboratories, or Centers to adapt this Actinic Hygiene Plan for their specific operations and hazards. A Accustomed Operating Activity (SOP) Arrangement is independent in this Allotment to accommodate abetment to chic cadre breeding specific assurance procedures.

Part IV. Added Authoritative Accoutrement contains admonition and procedures capital to a acknowledged actinic hygiene affairs that abode activities added than the absolute administering and use of chancy chemicals. These added authoritative accoutrement accommodate admonition on MIT’s Environment, Bloom and Assurance Administering System; above-mentioned approval and accretion requirements; medical evaluations and assessments; almanac keeping; chic inspections and audits; acquiescence and enforcement; and added accompanying federal regulations that appulse actinic use at MIT.

2.       ROLES AND RESPONSIBILITIES

An capital basal of any actinic hygiene affairs is to acutely bright and analyze the altered roles and responsibilities of all the stakeholders who assignment or appointment in areas breadth chemicals are present. Allegorical roles and responsibilities for implementing the Actinic Hygiene Plan (CHP) will authorize accountability, accrue processes, enhance safety, and abstain abashing and questions in affair the Plan’s objectives.

2.1.    The DEPARTMENT HEAD

The DEPARTMENT HEAD for DMSE is Prof. Edwin Thomas.  The Administration Arch shall:

A.      Ensure the Actinic Hygiene Plan is written, and updated.  

B.      Appoint the Actinic Hygiene Officer (CHO). The abandoned alleged charge be able by training or acquaintance to accommodate abstruse admonition in the development and accomplishing of this accounting Actinic Hygiene Plan. This abandoned charge accept adapted ascendancy to abetment with accomplishing and administering of the Actinic Hygiene Plan. 

C.      Accommodate or admission authoritative and banking support, as needed, for implementing and advancement the Actinic Hygiene Plan and the requirements of the Plan.

2.2.    The CHEMICAL HYGIENE OFFICER

The CHEMICAL HYGIENE OFFICER for DMSE is Prof. David Roylance. The Actinic Hygiene Officer shall:

A.      Apperceive and accept the requirements of the OSHA Chic Accustomed adjustment (29CFR 1910.1450) and the DMSE Actinic Hygiene Plan.

A.      Oversee the accomplishing of the CHP in the Department, Lab, or Center and abetment Arch Investigators or Admiral (PI/Supervisors) with implementing the Actinic Hygiene Plan aural their laboratory.

B.      Ensure the Plan is broadcast or fabricated attainable to all in the DMSE who are impacted by the Plan.

C.      Abide one archetype of the CHP electronically to the MIT Environment, Bloom and Assurance (EHS) Office for advertence use and to facilitate the anniversary amend process.

D.      Advise Arch Investigators or Admiral apropos able facilities, controls, and procedures for assignment with almighty chancy chemicals.

E.      Seek agency to beforehand the Actinic Hygiene Plan.

F.      Assay and amend the Actinic Hygiene Plan annually, aback directed by the EHS Office.

G.     Abutment the EHS Coordinator, as needed, with assay and assay activities and added requirements of the EHS Administering System, such as the Amplitude Registration Database.

H.      Participate in assay of austere accidents involving chancy chemicals, acting as a communication to the EHS Office.

I.         Abetment PI/Supervisors, as needed, with accepting casework or aliment and accessories for acclimation actinic hygiene problems or acclamation actinic hygiene needs.

J.       Ensure alternate acknowledgment ecology requirements are met and beforehand ecology records.

A.      If requested, assay proposed abstracts for cogent environment, health, and assurance issues, and/or acquaintance the EHS Office to abode concerns.

B.      Co-Chair the DMSE-EHS Committee with the EHS Coordinator.

C.      Attend anniversary CHO affair conducted by the EHS Office.

2.3.    The EHS COORDINATOR

The ENVIRONMENT, HEALTH AND SAFETY (EHS) COORDINATOR for DMSE is Mr. Joseph Glogowski, who shall:

A.      Accommodate abetment to the CHO, if adapted and as requested, with developing and implementing the DMSE Actinic Hygiene Plan.

B.      Be accustomed with the DMSE Actinic Hygiene Plan.

C.      Compile admonition from the chic for the EHS Amplitude Registration Database.

D.      Ensure accustomed inspections are conducted in the chic areas.

E.      Participate in biannual inspections of chic operations.

F.      Ensure DMSE agents accept training adapted by adjustment for safe administering and able auctioning of chemicals and that the training is documented.

G.     Serve as acquaintance point for alignment adapted studies or abutment from the EHS Office.

H.      Act as a acquaintance for Architecture Casework and Repair and Aliment agents to abode apropos apropos assurance for assignment in the chic area.

I.         Ensure adapted bounded annal are calm and maintained for inspections, assay follow-up, and lab-specific training for three years.

J.       Align for decommissioning of chic space.

2.4.    The PRINCIPAL INVESTIGATOR or LABORATORY SUPERVISOR

The PRINCIPAL INVESTIGATOR or LABORATORY SUPERVISOR (PI/Supervisor) shall:

A.      Be accustomed with this Actinic Hygiene Plan and ensure that all assignment is conducted in accordance with requirements of this Plan. They should acquaintance the CHO for admonition and abetment apropos this Plan and implementing the accoutrement of this Plan aback needed.

B.      Assess all chemicals in the assay laboratories beneath their purview, and ensure measures are accustomed for safe use, storage, and auctioning of the chancy chemicals aural the laboratory.  Such measures include:

1.       Advancing additional, Accustomed Operating Procedures (SOPs) for assay activities involving chancy chemicals, aback needed. See Allotment II. Breadth 3. for added admonition on aback added SOPs are required.

2.       Accouterment claimed careful accessories bare for safe administering of the chemicals.

3.       Accouterment able containers, containment, and cabinetry for safe accumulator of materials.

4.       Defining the breadth and processes breadth decidedly chancy substances will be used, ensuring these areas are labeled, and ensuring that a account of these substances is maintained.

C.      Ensure new processes or abstracts involving chancy abstracts are planned anxiously and adapted hazard information, assurance equipment, and SOPs are attainable above-mentioned to basal work.  Consistently seek to abbreviate the aggregate of chancy chemicals purchased and acclimated for abstracts or processes.

D.      Ensure the admonition apropos the chic activities recorded in the Amplitude Registration Database is accurate.

E.      Plan for accidents and ensure that adapted aliment are in abode and procedures are accustomed for responding to an accident, including charwoman up actinic spills.

F.      Ensure all advisers alive in the chic accept adapted training for assignment with potentially chancy chemical, including lab-specific training on the chancy abstracts that they use.  See Allotment I. Breadth 3.  Chase procedures for documenting the lab-specific training.

G.     Ensure that all cadre admission medical examinations and participate in the MIT medical surveillance affairs aback adapted due to the abstracts they are alive with.

H.      Adviser the assurance achievement of the agents to ensure that the adapted assurance equipment, practices and techniques are accustomed and are actuality alive and ensure that activity is taken to actual assignment practices that may beforehand to actinic exposures or releases.

I.         Aback needed, acquaintance the Environment, Bloom and Assurance (EHS) Office to align for abode air samples, swipes or added tests to actuate the aggregate and attributes of aerial and/or credible contamination, acquaint advisers and acceptance of the results, and use abstracts to aid in the appraisal and aliment of adapted chic conditions.

J.       Ensure chic inspections are conducted routinely, and abode all areas assigned in the Akin I. and II. Inspections as categorical in Allotment IV. Breadth 6. Booty activity to actual altitude that may beforehand to accidents or acknowledgment to chancy chemicals, and to actual problems articular during inspections. See Allotment IV. Breadth 6. for added information.

K.      Ensure advisers who doubtable they may accept accustomed an boundless acknowledgment to a chancy actinic abode to the MIT Medical Administration for assessment.  Such exposures may activity through adventitious inoculation, ingestion, or assimilation of the chemical.

L.       Abode all accidents involving an employee’s actinic acknowledgment or involving a actinic discharge that may aggregate a crisis of ecology contagion to the EHS Office, the CHO or EHS Coordinator. 

M.     Investigate all actinic accidents and a misses to actuate the account and booty adapted antidotal activity to anticipate agnate accidents.  Acquaintance the CHO or the EHS Office, aback needed, for abetment with investigations, assessment, and recommendations for antidotal action.

N.      Ensure exceptionable or antithesis chancy chemicals and abstracts are appropriately disposed according to all MIT, state, and federal procedures.

O.     Abetment the EHS Office, EHS Coordinator, and CHO as requested.

2.5.    The EHS REPRESENTATIVE

The ENVIRONMENT, HEALTH AND SAFETY (EHS) REPRESENTATIVE shall:

A.      Be accustomed with the agreeable and requirements of this Actinic Hygiene Plan and abetment the Arch Investigator or Supervisor, as directed, with implementing and acknowledging with requirements of this Plan.

B.      Abetment with contacting the DMSE EHS Coordinator or the CHO, aback needed, for abetment with acclamation requirements for safe administering of chemicals.

C.      Abetment with or accommodate lab-specific actinic hygiene training for chic personnel, as directed by the PI/Supervisor.

D.      Abetment with broadcasting of EHS admonition to chic personnel.

E.      Abetment with adapted accustomed inspections of the laboratory, acclimation problems that can be readily corrected.

F.      Abetment with ensuring capital aliment and accessories are in abode for safe assignment in the laboratory.

G.     Abetment with ecology agents assignment practices for safety.

H.      Abode assurance problems or apropos to the PI/Supervisor and/or the EHS Coordinator.

I.         Address, as directed, assurance problems or apropos in the laboratory.

J.       Assay and be accustomed with DMSE Emergency Preparedness Plan.

2.6.    The ENVIRONMENT, HEALTH and SAFETY (EHS) OFFICE

The ENVIRONMENT, HEALTH, and SAFETY (EHS) OFFICE shall:

A.      Oversee activity for anniversary amend of the CHP, reminding CHOs and EHS Coordinators aback anniversary CHP updates are due and reviewing adapted plans.  See the CHP Preparer’s Adviser on the CHP website (http://web.mit.edu/environment/ehs/chp.html) for added admonition on the anniversary amend process.

B.      Accommodate a accustomed CHP arrangement for use in developing and afterlight Actinic Hygiene Plans.

C.      Accommodate “General Actinic Hygiene” training by classroom, web, or aback requested by DMSE.

D.      Accommodate “Managing Chancy Waste” training by classroom, web, or aback requested by a DMSE.

E.      Accommodate abstracts and admonition to abetment with Lab-Specific Actinic Hygiene Training.

F.      Authorize and beforehand a arrangement for advancement training records.

G.     Conduct an anniversary affair for CHOs and EHS Coordinators to amend them apropos changes in the Template, the EHS Administering System, and to assay cogent actinic assurance apropos from the year.

H.      Conduct adapted investigations and acknowledgment monitoring, as requested or as adapted by regulations, authoritative recommendations for ascendancy aback needed.

I.         Participate in inspections of chic operations at atomic already a year.

J.       Oversee the anger awning assay program.

K.      Accommodate admonition apropos alternative and use of claimed careful equipment.  Aback respirators are required, accommodate casework to ensure cadre are provided the able equipment, to ensure the accessories fits properly, and to ensure users accept the adapted training.

L.       Accommodate admonition and assay accustomed operating procedures (SOPs) for new abstracts or operations, as requested.

M.     Provide, as requested, actinic assurance admonition and admonition for adapted controls of hazards such as able claimed careful accessories and bounded bankrupt ventilation.

N.      Abetment with investigations of austere accidents or actinic acknowledgment incidents.

O.     Abode all DMSE-specific accidents and incidents, as appropriate, to the DMSE EHS Coordinator.

2.7.    EMPLOYEES, STAFF, STUDENTS, and VISITORS

Employees, staff, students, and visitors alive with or about chancy chemicals in a chic shall:

A.      Apprehend and accept the OSHA Actinic Chic Accustomed and this Actinic Hygiene Plan.

B.      Accept the hazards of chemicals they handle and the signs and affection of boundless exposure.

C.      Accept and chase all accustomed operating procedures.

D.      Accept and administer all training received.

E.      Accept the activity and able use of all claimed careful accessories and abrasion claimed careful accessories aback allowable or necessary.

F.      Abode to the Arch Investigator or Chic Administrator any cogent problems arising from the accomplishing of the accustomed operating procedures.

G.     Abode to the PI/Supervisor all facts pertaining to every blow that after-effects in acknowledgment to baneful chemicals.

H.      Abode to the PI/Supervisor or EHS Representative accomplishments or altitude that may abide that could aftereffect in an accident. 

I.         Acquaintance the PI/Supervisor, the Actinic Hygiene Officer, the EHS Coordinator, or the EHS Office if any of the aloft procedures are not acutely understood.

J.       If an emergency occurs accompanying to an experiment, accommodate emergency acknowledgment cadre with admonition about the altitude that acquired the emergency and the absolute bearings in the laboratory.

2.8.    DMSE EHS COMMITTEE

DMSE has an EHS Committee, as adapted by the Institute.  Its accustomed associates are

Prof. David Roylance, DMSE Actinic Hygiene Officer, Committee Chair

Mr. Joseph Glogowski, DMSE EHS Coordinator

Ms. Rhonda O’Keefe, EHS DMSE Beforehand Contact

Prof. Ned Thomas, DMSE Head

Prof. Michael Rubner, CMSE Director

Mr. Gerald Hughes, DMSE Accessories Coordinator

 

The Committee is adapted to accommodated at atomic already anniversary year.  With account to the Actinic Hygiene Plan, the DMSE EHS Committee shall:

A.      Participate in alternate inspections and/or assay assay letters of DMSE’s laboratories and facilities, accouterment admonition or directives, as needed, for acclimation problems found.

B.      Assay actinic administering incidents or acknowledgment issues that activity in DMSE and acclaim adapted antidotal action.

3.       TRAINING

MIT has accustomed systems to ensure you are provided with OSHA-required training to acquaint you of the hazards and precautions for assignment with chemicals, including chemicals present in your assignment area.  The activity begins aback you complete a web-based Training Needs Assessment.  You acknowledgment questions specific to your assay bearings and job duties, and the arrangement will accommodate you admonition on your training needs and requirements.  You should again beforehand to booty the adapted web courses, or assurance up for classroom training.  As a researcher or abettor alive in a chic at MIT, you charge complete the Training Needs Assessment, and can do so by activity to http://web.mit.edu/environment/training.  This will booty you to a folio that will absolute you further.  If you accept problems or questions apropos commutual the Training Needs Assessment, you should acquaintance your EHS Coordinator or your EHS Representative.

3.1.    Training Requirements

Chemical hygiene training requirements are abundant in the EHS-MS training system, which can be accessed at http://mit.edu/environment/training.  The afterward four accoutrement are adapted if you announce in the Training Needs Appraisal aural the training arrangement that you use potentially chancy chemicals in a laboratory, or you are a Arch Investigator or Administrator for those who use potentially chancy chemicals in a laboratory.

 

A.      Accustomed Actinic Hygiene Training – can be taken as a web-based beforehand or taken by accessory a chic offered by the Environment, Bloom and Assurance (EHS) Office.  This beforehand is adapted abandoned already afore alpha assignment with potentially chancy chemicals in a laboratory.

A.      Apprehend the Actinic Hygiene Plan – Signing a acceptance of accepting apprehend and accustomed the Plan is adapted one time afore alpha assignment with potentially chancy chemicals in a laboratory.

B.      Lab-Specific Actinic Hygiene Training – provided by the Arch Investigator or his or her designee on lab-specific actinic hazards.  Adapted afore alpha assignment with potentially chancy chemicals in a chic and annually thereafter (usually aural a lab accession meeting).   The capacity covered will depend, in part, on the attributes of the lab and assay actuality done.  Altercate Lab-Specific Actinic Hygiene Training questions and requirements with your PI/Supervisor, EHS Representative, Actinic Hygiene Officer or your EHS Coordinator.

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C.      Managing Chancy Decay – can be taken as a web-based beforehand or taken by accessory a chic offered by the EHS Office.  Adapted afore alpha assignment with potentially chancy chemicals and annually thereafter.

3.2.    Training Records

The PI/Supervisor or designee will accrue a archetype of the outline of the capacity covered in Lab-Specific Actinic Hygiene Training.  The agenda or lists of advisers who accept completed the lab-specific training and apprehend the Actinic Hygiene Plan, will be submitted to the EHS Coordinator. These training annal are again entered into the EHS-MS Axial Training Annal Database. Training annal are kept for at atomic 3 years afterwards an abettor or apprentice leaves the Institute.

4.       INFORMATION REQUIREMENTS

4.1.    Basal Requirements

Information that charge be attainable to chic cadre includes:

A.      A archetype of the OSHA Chic Accustomed and its Appendices. The Chic Accustomed can be accessed on the OSHA website via http://www.osha.gov and analytic beneath the adjustment cardinal “1910.1450”.

B.      The Permissible Acknowledgment Banned (PELs) for OSHA-regulated substances and the American Conference of Governmental Industrial Hygienists (ACGIH) Alpha Absolute Ethics (TLVs) for chancy substances not accustomed OSHA PELs. These lists are provided via a web articulation in Appendix II-A and II-B of this document.

C.      Signs and affection associated with acknowledgment to chancy substances acclimated in the laboratory. Accustomed admonition is chip into Allotment II. Sections 2. and 3. of this document.

D.      The breadth and availability of accustomed advertence abstracts on hazards, safe handling, accumulator and auctioning of chancy chemicals activate in the laboratory. This admonition is provided in the aing breadth of this document.

In addition, your supervisor, Actinic Hygiene Officer, EHS Coordinator and EHS Office agents are attainable to accommodate assurance information. Aggregate assurance admonition sources are discussed below.

4.2.    Actinic Assurance Admonition Sources

4.2.1.        Actual Assurance Abstracts Sheets (MSDSs)

Material Assurance Abstracts Sheets (MSDSs) are documents, able by actinic manufacturers, that accommodate admonition about the chemical’s authentic and actinic hazards and recommended acknowledgment limits, and account the agency for authoritative those hazards. MSDSs additionally accommodate admonition about aboriginal aid, emergency procedures, and decay disposal.

An MSDS should be brash afore alpha assignment with a actinic to actuate able use and assurance precautions. Already a actinic is present in the lab, the MSDS should be either book credible electronically or a adamantine archetype kept on duke for reference, or in case of emergencies. Specific admonition adapted by OSHA to be on an MSDS includes:

      Artefact Identity                                     Acuteness Hazards

      Chancy Ingredients                            Discharge Clean-Up

      Physical/Chemical Properties                 Careful Equipment

      Blaze and Admission Hazards                    Adapted Precautions

      Bloom Hazards and Acknowledgment Limits

MSDSs and added actinic hazard admonition can be acquired from a array of sources as categorical below:

A.      The Internet. The EHS Office has aggregate a account of links to sites that accommodate MSDSs. This account can be accessed at http://web.mit.edu/environment/ehs/topic/msds.html.

B.      Actinic Manufacturer. A appeal may be fabricated anon to the actinic architect or supplier. This is about the best antecedent for “products” or “mixtures” to actuate what chancy capacity are independent in the formulation.

C.      EHS Office. A book of MSDSs for accustomed chemicals that are in use at MIT or accept been acclimated at MIT is attainable through the EHS Office on the fourth attic of Architecture N52. They can be accomplished at 617-452-3477 (2-EHSS or 2-3477 from an MIT telephone).

Please acquaintance the EHS Office if you charge abetment in interpreting MSDS information.

4.2.2.        Anew Actinic Chemicals and MSDS Requirements

New actinic substances actinic or produced in your chic and acclimated or aggregate alfresco of your chic apartment are answerable to OSHA Hazard Communication Accustomed (29 CFR 1910.1200) requirements.  These rules allotment the alertness of a Actual Assurance Abstracts Breadth for anniversary actinic actuality and labeling of containers absolute the actinic substance.

4.2.3.        Chic Actinic Assurance Summaries (LCSS)

The LCSSs accommodate concise, analytical discussions of the toxicity, flammability, reactivity, and explosibility of 88 chemicals frequently acclimated in authentic assay laboratories. These are decidedly advantageous as they abode chic use of chemicals. They are attainable from the Howard Hughes Medical Institute website at http://hhmi.org/research/labsafe/overview.html.

4.2.4.        Actinic Alembic Labels

Chemical alembic labels are a acceptable adeptness for admonition on actinic hazards. All containers of chancy chemicals charge accept labels attached. Labels on purchased chemicals charge include:

q       The accustomed name of the chemical;

q       The name, abode and blast cardinal of the aggregation amenable for the product; and

q       Adapted hazard warning(s).

The admonishing may be a distinct chat (e.g. Danger, Caution, Warning) or may analyze the primary hazard both authentic (e.g. baptize reactive, flammable, or explosive) and bloom (e.g. carcinogen, acerb or irritant).

Most labels accommodate added assurance admonition to admonition workers assure themselves from the substance. This admonition may accommodate careful measures and/or careful accouterment to be used, aboriginal aid instructions, accumulator admonition and emergency procedures.  

Laboratory cadre are amenable for:

q       Inspecting admission containers to be abiding that labels are captivated and are in acceptable activity and accommodate the admonition categorical above.

q       Account the alembic characterization anniversary time a anew purchased actinic is used. It is attainable that the architect may accept added new hazard admonition or reformulated the artefact aback the aftermost purchase.

q       Ensuring that actinic alembic labels are not removed or defaced, except aback containers are empty.

q       Labeling any accessory containers acclimated in the laboratory, to anticipate alien chemicals or careless reaction.

q       Verifying that actinic decay containers accept complete and authentic actinic decay labels.

Additional admonition on labeling actinic containers can be activate in Allotment II. Breadth 6.

4.2.5.        Environment, Bloom and Assurance Advertence Literature

The EHS Office maintains a library of advertence abstracts acclamation environment, bloom and assurance issues. These references accommodate applicative acknowledgment standards and recommended acknowledgment levels, as able-bodied as copies of the OSHA Lab Accustomed and its Appendices. These materials, as able-bodied as added bloom and assurance references, may be brash by visiting the EHS Office amid on the fourth attic of Architecture N52.

 

PART II. Accustomed Actinic Hygiene Practices

1.       INTRODUCTION

Part II. of this Actinic Hygiene Plan contains the minimum adapted precautions and accustomed operating procedures for alive with chic chemicals in MIT laboratories. These precautions abode ample classes of chemicals.  This Allotment contains actinic hazard and blow appraisal information, and accustomed procedures for safe actinic administering acclamation the purchase, use, labeling, storage, auctioning and aircraft of chemicals.  This Allotment additionally discusses accustomed controls for safe use of chemicals including authoritative and engineering controls, such as anger hoods, claimed careful equipment, and appointed areas.

Hazardous chemicals can account abuse aback they admission the anatomy in acceptable amounts via inhalation, ingestion, bang or bark absorption. Adverse furnishings can additionally activity by eye or bark acquaintance alone. The attributes of the chancy actinic and the routes by which it enters or contacts the anatomy actuate the blazon of controls that are needed. The Anatomic Assurance and Bloom Administering (OSHA) and added organizations accept set anatomic acknowledgment banned on aerial actinic exposure. Befitting exposures beneath these banned is about believed to assure advisers and students. Permissible Acknowledgment Banned (PELs) set by OSHA are independent in Appendix II-A. Alpha Absolute Ethics (TLVs) accustomed by the American Conference of Governmental Industrial Hygienists (ACGIH) are independent in Appendix II-B. For abounding chic chemicals, acknowledgment banned accept not been established.  In addition, little is accustomed about the furnishings of accumulated exposures.  Therefore, all chic workers should booty accomplish to abbreviate actinic acknowledgment via all routes of entry.

OSHA recognizes that some classes of actinic substances affectation a greater bloom and assurance blow than others. To differentiate this altered blow characteristic, OSHA identifies two categories of chancy chemicals: chancy chemicals and decidedly chancy substances.  Decidedly chancy substances (PHSs) is a subset of chancy chemicals that is adapted added stringently because they accept been accounted to affectation a essentially greater risk. Because of this, OSHA requires added precautions and procedures be undertaken aback decidedly chancy substances are acclimated in the laboratory.

Introduction to Accustomed Operating Procedures

A accustomed operating activity (SOP) is a accounting set of instructions or guidelines that detail the accordant procedures to be followed routinely, and assurance precautions to booty aback accustomed out a authentic acceding or procedure. The development and accomplishing of accustomed operating procedures for analytical activities is a aggregate basal of announcement arete in a chic and for ensuring a safe, healthy, and environmentally complete workplace. For these reasons, the development of SOPs is an capital authoritative accoutrement to be acclimated in the chic and is a accoutrement that is adapted by the OSHA Chic Standard.

Literally bags of altered compounds are circuitous in the assay actuality conducted in campus laboratories.  The specific bloom hazards associated with abounding of these compounds are unknown, and abounding substances are new compounds which accept not been appear ahead in the actinic literature.  Consequently, it is absurd in this Actinic Hygiene Plan to accommodate accustomed operating procedures for anniversary specific chancy substances.  Instead, this Allotment outlines accustomed procedures that should be alive in the use of all chancy substances.  Abandoned assay groups may be adapted to supplement these accustomed procedures with added accustomed operating procedures for administering specific chancy substances that are acclimated in their laboratories.

This Actinic Hygiene Plan contains aggregate accustomed operating procedures for the safe use of two categories of chemicals: chancy chemicals, and decidedly chancy substances (PHS). These accustomed operating procedures are independent in Allotment II. Breadth 3. These accustomed assurance procedures are brash to ensure basal levels of agents bloom and assurance in the laboratory, for accustomed and accustomed practices, uses, and chemicals.

You are adapted to beforehand added accounting accustomed operating procedures if the accustomed SOPs provided in Allotment II. of this Plan DO NOT abundantly ensure the aegis of claimed bloom and safety, and the ambiance for a authentic activity, operation, or acceding conducted in your laboratory. This claim is decidedly applicative if a activity requires abundant and specific admonition to abstain alarming exposures or after-effects such as an explosion. SOPs charge be developed above-mentioned to initiating any decidedly chancy procedures.

Guidelines and a arrangement for advancing SOPs aback adapted as acclaimed above, are independent in Allotment III. of this Plan. A archetype of all SOPs developed charge be amid in the chic spaces, and be attainable to all bodies in the laboratory. It is recommended, but not required, that all added SOPs be included in Allotment III. of this Actinic Hygiene Plan.

Prior to alive with chemicals afterward the SOPs in Allotment II. Breadth 3, there are assertive accomplish you charge booty to accept the hazards of the assignment you are accomplishing with chemicals. A activity for assessing the hazards of actinic use is categorical below.

2.       IDENTIFICATION AND CLASSIFICATION OF HAZARDOUS CHEMICALS

Determine the specific chemicals you are alive with and the blazon of hazard they present. Abounding of the substances encountered in the chic are accustomed to be baneful or corrosive, or both.  Compounds that are atomic and/or are awful burnable affectation accession cogent blazon of hazard.  New and abstinent substances that may be chancy are additionally frequently encountered.  Thus, it is capital that all chic workers accept the types of toxicity, admit the routes of exposure, and are accustomed with the aloft hazard classes of chemicals.  The best important distinct generalization apropos toxicity in actinic assay is to amusement all compounds as potentially harmful, abnormally new and alien materials, and assignment with them beneath altitude to abbreviate acknowledgment by bark acquaintance and inhalation.

When because attainable toxicity hazards while planning an experiment, it is important to admit that the aggregate of the baneful furnishings of two substances may be decidedly greater than the baneful aftereffect of either actuality alone.  Because best actinic reactions are acceptable to accommodate mixtures of substances whose accumulated toxicities accept never been evaluated, it is adapted to accept that mixtures of altered substances (e.g., actinic acknowledgment mixtures) will be added baneful than the best baneful additive independent in the mixture.  Furthermore, actinic reactions involving two or added substances may anatomy acknowledgment articles that are decidedly added baneful than the starting reactants.

The OSHA Chic Accustomed defines a chancy actinic as “a actinic for which there is statistically cogent affirmation based on at atomic one abstraction conducted in accordance with accustomed authentic attack that astute or abiding bloom furnishings may activity in credible employees.  The appellation ‘health hazard’ includes chemicals which are carcinogens, baneful or awful baneful agents, changeable toxins, irritants, corrosives, sensitizers, hepatotoxins, nephrotoxins, neurotoxins, agents which act on the hematopoietic systems, and agents which blow the lungs, skin, eyes, or aing membranes”.  Awful burnable and atomic substances comprise a chic of chancy chemicals.

The aloft classes of chancy and decidedly chancy chemicals and their accompanying bloom and assurance risks are discussed in added detail below.

2.3.    Attainable Beastly Carcinogens

Carcinogens are actinic or authentic agents that account cancer.  About they are chronically baneful substances; that is, they account blow afterwards again or long-duration exposure, and their furnishings may abandoned become axiomatic afterwards a continued cessation period.  Abiding toxins are decidedly insidious because they may accept no actual credible adverse effects. For a ample cardinal of compounds there is bound affirmation of carcinogenicity to animals from studies involving alpha animals.  These compounds should be handled appliance the accustomed procedures for assignment with chancy substances categorical in Allotment II. Breadth 3.1 and 3.2 below. 

Certain baddest carcinogens are classified as “particularly chancy substances” and charge be handled appliance the added adapted precautions declared in Allotment II. Breadth 3.3. Baddest carcinogens (defined in detail below) abide of compounds for which there is affirmation from beastly studies that acknowledgment can account cancer.  It is important to admit that some substances circuitous in assay laboratories are new compounds and accept not been subjected to testing for carcinogenicity. 

2.4.    Acerb Substances

As a bloom hazard, acerb substances account aition of, or alterations in, alive tissue by actinic activity at the armpit of contact.  Aloft classes of acerb substances accommodate able acids (e.g., sulfuric, nitric, hydrochloric, and hydrofluoric acids), able bases (sodium hydroxide, potassium hydroxide, and ammonium hydroxide), dehydrating agents (sulfuric acid, sodium hydroxide, phosphorus pentoxide, and calcium oxide), and acerbic agents (hydrogen peroxide, chlorine, and bromine). Affection of acknowledgment for assimilation accommodate a afire sensation, coughing, wheezing, laryngitis, conciseness of breath, nausea, and ing. For eyes, affection accommodate pain, claret attack eyes, tearing, and abashing of vision. For skin, affection may accommodate reddening, pain, inflammation, bleeding, baking and burns. As a authentic hazard, acerb substances may bite abstracts they appear in acquaintance with and may be awful acknowledging with added substances.  It is important to assay admonition apropos abstracts they corrode, and their acuteness with added substances, as able-bodied as admonition on bloom effects.

2.5.    Irritants

Irritants are authentic as non-corrosive chemicals that account capricious anarchic furnishings on alive tissue by actinic activity at the armpit of contact.  A advanced array of amoebic and asleep compounds, including abounding chemicals that are in a crumb or apparent form, are irritants and consequently, bark acquaintance with all chic chemicals should consistently be avoided.

2.6.    Sensitizers

A sensitizer (allergen) is a actuality that causes credible bodies to beforehand an allergic acknowledgment in accustomed tissue afterwards again acknowledgment to the substance.  Examples of allergens accommodate diazomethane, chromium, nickel, formaldehyde, isocyanates, arylhydrazines, benzylic and allylic halides, and abounding phenol derivatives.

2.7.    Burnable and Atomic Substances

A cardinal of awful burnable substances are in accustomed use in campus laboratories.  Atomic substances are abstracts that decompose beneath altitude of automated shock, animated temperature, or actinic action, with the absolution of ample volumes of gases and heat. Some materials, such as achromatize formers, may not be explosive, but may anatomy atomic substances over time.

2.8.    Chancy Substances with Baneful Furnishings on Specific Organs

Substances included in this chic accommodate (a) hepatotoxins (substances that aftermath alarmist blow such as nitrosamines and carbon tetrachloride); (b) nephrotoxins (agents causing blow to the kidneys such as assertive halogenated hydrocarbons); (c) neurotoxins (substances which aftermath their primary baneful furnishings on the afraid arrangement such as mercury, acrylamide, and carbon disulfide); (d) agents which act on the hematopoietic arrangement (such as carbon monoxide and cyanides which abatement claret activity and bankrupt the anatomy tissues of oxygen); and (e) agents which blow lung tissue such as asbestos and silica.

2.9.    Decidedly Chancy Substances

As discussed in beforehand sections of this Actinic Hygiene Plan, chancy chemicals are chemicals for which there is authentic affirmation that adverse astute or abiding bloom furnishings may activity in credible workers.  An abettor is an astute adulteration if its baneful furnishings are embodied afterwards a distinct or short-duration exposure.  Chronically baneful agents appearance their furnishings afterwards again or long-duration acknowledgment and the furnishings usually become axiomatic abandoned afterwards a continued cessation period.  Abounding of the substances in accustomed use in laboratories are classified as chancy substances, and the procedures for alive with these chemicals are abundant in Allotment II Breadth 3.1. and 3.2  There are some substances, however, that affectation such cogent threats to beastly bloom that they are classified as “particularly chancy substances” (PHSs).  The OSHA Chic Accustomed requires that adapted accoutrement be accustomed to anticipate the adverse acknowledgment of advisers to PHSs.  Accustomed procedures for alive with such abstracts are presented in detail in Breadth 3.3.

Chemicals are classified as decidedly chancy substances if they accord to one or added of the afterward three categories.  Compounds classified as decidedly chancy substances about charge again be handled appliance the procedures categorical in Allotment II. Breadth 3.3 in accession to the procedures categorical for chancy chemicals in Allotment II. Breadth 3.1 and 3.2.  Appendix II. C. provides procedures to abetment you in how to actuate if a actinic is a decidedly chancy substance, as able-bodied as added admonition on PHSs.

2.9.1.        Baddest Carcinogens

Certain almighty carcinogens are classified as “select carcinogens” and brash as PHSs.  A baddest carcinogen is authentic in the OSHA Chic Accustomed as a actuality that meets one of the afterward criteria:

q       It is adapted by OSHA as a carcinogen,

q       It is listed as “known to be a carcinogen” in the latest Anniversary Abode on Carcinogens appear by the National Toxicology Affairs (NTP),

q       It is listed beneath Accession 1 (“carcinogenic to humans”) by the International Agency for Assay on Blight (IARC), or

q       It is listed beneath IARC Accession 2A or 2B, (“probably baleful to humans”) or beneath the chic “reasonably advancing to be a carcinogen” by the NTP, and causes statistically cogent bump blow in alpha animals in accordance with any of the afterward criteria: (i) afterwards assimilation acknowledgment of 6-7 hours per day, 5 canicule per week, for a cogent allocation of a lifetime to dosages of beneath than 10 mg/m3; (ii) afterwards again bark appliance of beneath than 300 mg/kg of anatomy weight per week; or (iii) afterwards articulate dosages of beneath than 50 mg/kg of anatomy weight per day.

The afterward Table lists the substances affair belief (a), (b), or (c).  For admonition on compounds affair belief (d), appraise IARC Accession 2A and 2B lists and the NTP lists that are attainable on the Internet. See Appendix II-C for added admonition on PHSs.

Partial Account of Baddest Carcinogens (Includes OSHA Carcinogens)

2-acetylaminofluorene

acrylamide

acrylonitrile

4-aminodiphenyl

arsenic and assertive arsenic compounds

asbestos

azathioprine

benzene

benzidine

bis(chloromethyl) ether

1,3 butadiene

1,4-butanediol dimethylsulfonate (myleran)

cadmium

chlorambucil

chloromethyl methyl ether

chromium and assertive chromium compounds

coal-tar pitches

coal tars

coke oven emissions

conjugated estrogens

cyclophosphamide

1,2-dibromo-3-chloropropane

3,3′-dichlorobenzidine (and its salts)

diethylstilbestrol

dimethylaminoazobenzene

dimethyl sulfate

ethylene dibromide

ethylene oxide

ethylenimine

formaldehyde

hexamtehylphosphoramide

hydrazine

melphalan

4,4′-methylene-bis(2-chloroaniline)

methylene chloride

methylene dianiline

mustard gas

N,N’-bis(2-chloroethyl)-2-naphthylamine (chlornaphazine)

alpha-naphthylamine

beta-naphthylamine

nickel carbonyl

4-nitrobiphenyl

N-nitrosodimethylamine

beta-propiolactone

thorium dioxide

treosulphan

vinyl chloride

Note:  the aloft account is not brash to be complete, and it is the albatross of the researcher (in appointment with their chic supervisor) to appraise anniversary admixture circuitous in their assignment and to actuate whether it should be handled as a baddest carcinogen.

2.9.2.        Changeable and Adorning Toxins 

Reproductive toxins can affect the changeable bloom of both macho and changeable advisers and acceptance if able procedures and controls are not used. For women, acknowledgment to changeable toxins during abundance can account adverse furnishings on the fetus; these furnishings accommodate embryolethality (death of the fertilized egg, antecedent or fetus), malformations (teratogenic effects), and postnatal anatomic defects.  Examples of embryotoxins accommodate thalidomide and assertive antibiotics such as tetracycline.  Women of bearing abeyant should agenda that embryotoxins accept the greatest appulse during the aboriginal trimester of pregnancy.  Because a woman about does not apperceive that she is abundant during this aeon of aerial susceptibility, adapted assimilation is brash aback alive with all chemicals, abnormally those rapidly captivated through the bark (e.g., formamide).  Abundant women and women intending to become abundant should argue with their chic administrator and the Environment, Bloom and Assurance (EHS) Office afore alive with substances that are doubtable to be changeable toxins.  As basal precautions, the accustomed procedures categorical in Allotment II. Breadth 3.3 beneath should again be followed for assignment with such compounds.  For men, the affects of assertive changeable toxins may accommodate abatement in fertility, malformations in off-spring, and assertive types of cancer. Therefore, able aegis from acknowledgment charge be employed.

Information on changeable toxins can be acquired from Actual Assurance Abstracts Sheets, by contacting the EHS Office Industrial Hygiene Affairs (617-452-3477).  

The afterward Table lists some accustomed abstracts that are doubtable to be changeable toxins; in best laboratories it will be adapted to handle these compounds as decidedly chancy substances.

Partial Account of Changeable Toxins

arsenic and assertive arsenic compounds

benzene

cadmium and assertive cadmium compounds

carbon disulfide

ethylene glycol monomethyl and ethyl ethers

ethylene oxide

lead compounds

mercury compounds

toluene

vinyl chloride

xylene

Note:  The aloft account is not brash to be complete, and it is the albatross of the researcher (in appointment with their chic supervisor) to appraise anniversary admixture circuitous in their assignment and to actuate whether it should be handled as a changeable toxin.

2.9.3.        Compounds with a Aerial Aggregate of Astute Toxicity

Compounds that accept a aerial aggregate of astute toxicity comprise a third chic of decidedly chancy substances as authentic by the OSHA Chic Standard.  Acutely baneful agents accommodate assertive acerb compounds, irritants, sensitizers (allergens), hepatotoxins, nephrotoxins, neurotoxins, agents that act on the hematopoietic systems, and agents which blow the lungs, skins, eyes, or aing membranes.  Substances that accept a aerial aggregate of astute toxicity are interpreted by OSHA as actuality substances that “may be baleful or account blow to ambition organs as the aftereffect of a distinct acknowledgment or exposures of abbreviate duration”. 

Toxic and Awful Baneful Agents

OSHA regulations (29 CFR 1910.1200 Appendix A) ascertain baneful and awful baneful agents as substances with average baleful dosage (LD50) ethics in the afterward ranges:

Test                                    Toxic                                                   Awful Toxic

Oral LD50                             50-500 mg/kg                                        <50 mg/kg

(albino rats)

Skin Acquaintance LD50                                 200-1000 mg/kg                                     <200 mg/kg

(albino rabbits)

Inhalation LC50                     200-2000 ppm/air                                   <200 ppm/air

(albino rats)

It is important to agenda that the aloft allocation does not booty into appliance abiding toxicity (e.g. carcinogenicity and changeable toxicity).  Also, agenda that LD50 ethics alter decidedly amid altered species, and the beastly toxicity for a actuality may be greater or beneath than that abstinent in assay animals. OSHA considers substances that are either baneful or awful toxic, as authentic above, to be decidedly chancy substances.

In evaluating the astute toxicity of actinic substances, the HMIS (Hazardous Abstracts Identification System) appraisement belief developed by the National Paint and Coatings Association may be helpful.  HMIS numbers can about be activate in MSDSs.  LD50 ethics can be activate in MSDSs and in references such as the Sigma-Aldrich Library of Actinic Assurance Abstracts and Patnaik’s A Absolute Adviser to the Chancy Backdrop of Actinic Substances.

The afterward Table lists some of the compounds that may be in accustomed use in campus laboratories and that accept a aerial aggregate of astute toxicity:

Partial Account of Compounds with a Aerial Aggregate of Astute Toxicity

abrin

nitrogen dioxide

acrolein

osmium tetroxide

arsine

ozone

chlorine

phosgene

diazomethane

ricin

diborane (gas)

sodium azide

hydrogen cyanide

sodium cyanide (and added cyanide salts)

GHS Secondary Labels, Roll of 14 - hmis label ppe codes
GHS Secondary Labels, Roll of 14 – hmis label ppe codes | hmis label ppe codes

hydrogen fluoride

strychnine

methyl fluorosulfonate

nickel carbonyl

Note:  the aloft account is not brash to be complete, and it is the albatross of the researcher (in appointment with their chic supervisor) to appraise anniversary admixture circuitous in their assignment and to actuate whether it is a actuality with a aerial aggregate of astute toxicity. 

Compounds classified as accepting a aerial aggregate of astute toxicity charge about be handled appliance the procedures categorical in Allotment II. Breadth 3.3 beneath in accession to the procedures categorical for chancy chemicals in Allotment II. Breadth 3.1 and 3.2.  Finally, several of the compounds listed may crave above-mentioned approval from the DMSE EHS Committee afore assignment with them can be agitated out.  See Allotment IV. Breadth 2. for a altercation of above-mentioned approval requirements.

In evaluating the hazards associated with assignment with baneful substances, it is important to agenda that a cardinal of factors admission the acknowledgment of individuals to acknowledgment to baneful compounds.  For example, bodies are rarely credible to a distinct biologically alive substance.  With this point in mind, it is noteworthy that one adulteration can admission the aftereffect of a second.  This underscores the accent of advancement acceptable chic practices at all times, and with all chemicals.

3.       STANDARD OPERATING PROCEDURES FOR WORK WITH HAZARDOUS CHEMICALS

3.1.    Basal Accomplish and Procedures

All assignment involving chemicals in MIT laboratories charge be conducted appliance the “Standard Operating Procedures” categorical below.  In addition, chic workers charge actuate whether any of the chemicals to be handled in the planned acceding accommodated the analogue of a decidedly chancy actuality due to aerial astute toxicity, carcinogenicity, and/or changeable toxicity.  If so, accede the absolute aggregate of the actuality that will be used, the accustomed abundance of use, the chemical’s routes of exposure, and the affairs of its use in the proposed experiment.  Use this admonition to actuate whether it is adapted to administer the “Additional Procedures for Assignment with Decidedly Chancy Substances” categorical in Allotment II. Breadth 3.3.  For actual baneful or chancy substances, or specialized practices, appliance charge be accustomed to whether added appointment with assurance professionals and development of specialized SOPs is acceptable or required.

STEP 1: Actuate the toxicity and admonishing backdrop of the chemicals to be acclimated in your experiment.

q       Analyze the chemicals circuitous in the proposed acceding and actuate the amounts that will be used.

q       Use an a LCSS or MSDS to actuate the acknowledgment limit, blazon of toxicity, admonishing backdrop (smell, irritation, etc.) and affection of acknowledgment for anniversary actinic circuitous in the planned experiment.

q       If a new actinic substance(s) will be produced during the acceding and the toxicity is unknown, accept it is a decidedly chancy actuality and chase the procedures in Allotment II. Breadth 3.3.

q       Accept that any admixture of chemicals will be added baneful than its best baneful component.

q       Accede substituting beneath baneful chemicals.

STEP 2: Actuate best acceptable routes of acknowledgment based on how chemicals will be acclimated and their physical/chemical properties.

q       Assimilation – Assimilation risks are accomplished aback airy liquids, gases, dusts, or mists are acclimated or generated.  Heating will admission the animation of liquids.  Pay authentic assimilation to chemicals with low acknowledgment limits.  Abeyant for assimilation is accomplished aback chemicals are acclimated on an attainable lab bench.  Use in amid accoutrement or actinic chic hoods decreases assimilation acknowledgment potential.

q       Bark Acknowledgment – Chances for bark acknowledgment abide for best chic actinic procedures. Aback the “skin” characters is listed in the acknowledgment absolute breadth of the MSDS, the actinic can be captivated through the complete skin.

q       Bang or assimilation – Not commonly a aloft avenue of acknowledgment if able administering procedures are used. Actuate whether the acceding involves a cogent blow of careless assimilation or bang of chemicals.

STEP 3: Actuate adapted ascendancy measures, claimed careful equipment, and able assignment practices to abbreviate exposure.

A.      Assimilation Ascendancy Measures

Determine Aback to Use Chic Actinic Hoods (Fume Hoods)

Procedures involving airy baneful substances and those operations involving solid or aqueous baneful substances that may aftereffect in the bearing of abasement or aerosols should be conducted in a chic awning or added blazon of bounded bankrupt ventilation.  See Allotment II. Breadth 5. for a added abundant altercation of chic hoods. Added types of ascendancy accessories accommodate cuff boxes, custom brash hoods, shut-off valves, and ecology accessories affiliated to alarms and shut-off valves.

Determine Whether Respirators Adeptness Be Required

Generally, hazards should be controlled by use of blast and it should not be all-important to use respirators. Acquaintance the Industrial Hygiene Affairs for admonition in evaluating the charge for a respirator.  If one is bare and you are medically able to abrasion a respirator, admission one of the actual blazon and admeasurement from the Industrial Hygiene Program.  Do not use a lab mate’s respirator. The MIT Respirator Aegis Affairs is declared in abounding at http://mit.edu/environment/ehs/respiratory.html. 

B.      Claimed Careful Accessories For Eyes and Bark

Select and abrasion adapted eye and face protection.

Wearing eye aegis is adapted by OSHA adjustment whenever and wherever abeyant eye hazards exist.  Hazards astute eye and/or face aegis accommodate aerial particles; aqueous metal; liquids including acids and abrasive materials, biological or radioactive materials; actinic gases or vapors; and potentially abusive ablaze radiation.  Abounding Departments, Labs and Centers crave eye aegis at all times in labs and shops, and column eye aegis adapted signs on the doors or in the chancy areas. Use assurance glasses with ancillary bouncer as basal eye aegis for administering chemicals breadth there is a low blow of burst or splatter.  Aback cloudburst ample amounts of chemicals, celebratory processes that are beneath calefaction or pressure, authoritative adjustments to actinic absolute apparatus, or assuming added operations or tasks with a abstinent to aerial abeyant burst blow or astringent after-effects in the blow of a splash, actinic goggles should be used.  A face absorber can be acclimated with the goggles to assure the face beneath these circumstances.. 

Wear adapted accouterment in the laboratory  aback alive with chancy substances.

Wear chic coats with continued sleeves.  Abrasion continued pants (trousers) or continued brim that awning your legs and shoes that awning your feet.  Do not abrasion sandals or open-toed shoes or shoes made of alloyed actual aback alive with chancy substances.  Confine continued beard and apart clothing.

 

Avoid bark acquaintance and assimilation of chancy substances by appliance adapted duke protection, careful clothing, and able assignment practices.

Contact with the bark is a accustomed approach of actinic injury.  A accustomed aftereffect of bark acquaintance is localized irritation, but an apparent cardinal of chancy substances are captivated through the bark with acceptable acceleration to aftermath systemic poisoning.  Assimilation of substances is rarely deliberate, but may activity because of contagion of easily administering food, contagion of accustomed assignment surfaces in the lab, and adventitious contagion of aliment or abstracts that appear in acquaintance with the mouth, and through poor assignment practices. Abstain acquaintance with, and assimilation of, chancy substances by demography the afterward precautions:

q       Baddest and abrasion adapted duke protection, about gloves, to anticipate abrasion to easily or acknowledgment by assimilation of chemicals through the bark of the hands.  Gloves for assignment with chemicals charge be alleged based on the abeyant acquaintance hazard, and the permeability of the cuff material.  For adventitious bark acquaintance with baby amounts of chemicals on a surface, or assignment with best powders, disposable nitrile gloves are usually adequate.  For assignment involving abstracts that are readily captivated through the skin, the cuff charge be anxiously alleged appliance cuff compactness charts.  Silver Absorber brand  gloves assignment able-bodied for abounding accustomed chic chemicals that can be captivated through the skin, but you should verify their effectiveness  for your application.  You should additionally appraise charge for duke aegis from authentic hazards such as astute calefaction or cold, and accomplish abiding you use adapted gloves.

q       Never use aperture suction to pipette chemicals or to alpha a siphon; a pipette ball or aspirator should instead be acclimated to accommodate vacuum.

q       Never aftertaste chic chemicals.

q       Ablution your easily with soap and baptize anon afterwards alive with chancy chemicals.

q       Eating, drinking, smoking, gum-chewing, and applying cosmetics in laboratories breadth chancy substances are in use is prohibited.  Do not abundance food, beverages, cups, or added bubbler and bistro accoutrement in areas breadth chancy chemicals are acclimated or stored.

q       Anon apple-pie up baby spills on assignment benches or in chic hoods.

Properly use and beforehand claimed careful accessories (PPE).

Personal careful accessories should be kept apple-pie and stored in an breadth breadth it will not become contaminated. Claimed careful accessories should be inspected above-mentioned to use to be abiding it is in acceptable condition.  It should fit appropriately and be beat properly.  If it becomes attenuated or damaged, it should be bankrupt or anchored or, in the case of disposable equipment, abandoned and replaced.

For added requirements and admonition on alternative of PPE, see Allotment II. Breadth 4. and appointment the EHS Office website at http://web.mit.edu/environment/ehs/ppe.html.

STEP 4: Be Able for Emergencies

Before alpha an experiment, apperceive what specific activity you will booty in the blow of the adventitious absolution of any chancy substances involved.  Apperceive the breadth and how to accomplish all assurance accessories including blaze blankets, eye washes, assurance showers, discharge carts and discharge ascendancy materials. Be accustomed with the breadth of the aing blaze anxiety and telephone, and apperceive what blast numbers to anxiety in the blow of an emergency.  Apperceive the breadth of the ambit breakers for your laboratory.

For all accidents astute emergency police, fire, or medical response, acquaintance Campus Badge at 617-253-1212 or 100 from an MIT telephone.

An MIT Emergency Acknowledgment Adviser should be acquaint in every chic in an breadth attainable to all. This adviser outlines the procedures to chase for best types of emergency situations. The MIT Emergency Acknowledgment Adviser is attainable electronically at http://web.mit.edu/environment/pdf/MITERG.pdf. Anxiously assay the guidelines for administering medical emergencies, claimed injury, actinic spills and blaze in the laboratory. This admonition could save your or your lab mate’s life.  Abandoned a subset of that admonition is again here.

In addition, Emergency Activity Affairs are adapted for anniversary Department, Laboratory, or Center (DLC) beneath the Anatomic Bloom and Assurance Administering (OSHA) regulations. All agents and acceptance should be accustomed with their laboratory’s Emergency Activity Plan, as it specifies the adapted acknowledgment and architecture avenue affairs for a array of life-safety emergency situations.

 

A.      Actinic Contamination

If the victim or their clothes are chemically contaminated, put on adapted claimed careful accessories and aish victim’s attenuated clothing. Appliance a actinic shower, eyewash, or bore in a safe area, flood attenuated anatomy part(s) with ample amounts of baptize for 15 minutes.

B.      Actual Assurance Abstracts Sheets (MSDS)

As time permits, and if you will not be placed at risk, attack to analyze the chemicals circuitous and admission MSDS’ or added accordant information. Accommodate the MSDS to the ambulance crew.

C.      Actinic Spills – Accessory vs. Major

Be able in advance. Accept discharge aliment attainable for the types of spills that adeptness occur. Apperceive beneath what affairs you should apple-pie up the spill, or aback you should abandon and seek help.

Minor chancy abstracts or decay spills that present no actual blackmail to cadre safety, health, or to the ambiance can be bankrupt up by chic cadre that use the abstracts or accomplish the waste.  A accessory chancy actual discharge is about authentic as a discharge of actual that is not awful toxic, is not agitated in ample quantity, does not present a cogent blaze hazard, can be recovered afore it is appear to the environment, and is not in a attainable breadth such as a accustomed hallway.  Such a discharge can usually be controlled and bankrupt up by one or two personnel.

Major chancy actual and decay spills should be appear to the MIT emergency cardinal (617-253-1212, or 100 from an MIT telephone) to accept actual able abetment and abutment in the ascendancy and apple-pie up of the agitated material.  Aloft chancy abstracts or decay spills are about authentic as accepting a cogent blackmail to safety, health, or the environment.  These  spills about are a awful baneful actual or is agitated in ample quantity, may present a cogent blaze hazard, cannot be recovered afore it is appear to the environment, or is agitated in a attainable breadth such as a accustomed hallway.  Aloft advertisement such a discharge cadre should stand-by at a safe ambit to adviser responders and discharge apple-pie up experts to the discharge area.  Advertisement cadre should additionally accrue added cadre from entering into the discharge area.

In the case of a discharge that presents a bearings anon alarming to activity or health, or a bearings with cogent blow of a fire, cadre should abandon the breadth and arouse emergency abetment by dialing the MIT emergency cardinal (617-253-1212, or 100 from an MIT telephone), activating a blaze anxiety station, or both.

3.2.    Capital Chic Assignment Practices

3.2.1.        Appropriately use, maintain, and actuate of chic glassware and added sharps.

Improper use of glassware is a accustomed account of injuries and accidents in the laboratory.

q       Careful administering and accumulator procedures should be acclimated to abstain damaging glassware.  Consistently anxiously analysis glassware for flaws and cracks afore use.  Damaged items should be abandoned or repaired.

q       Able duke aegis should be acclimated aback inserting canteen tubing into elastic stoppers or corks or aback acceding elastic tubing on canteen corrupt connections.  Tubing should be blaze able or angled and lubricated, and easily should be captivated aing calm to absolute movement of canteen should breach occur.  The use of artificial or metal connectors should be considered.

q       Glass-blowing operations should not be attempted unless able annealing accessories are available.

q       Vacuum-jacketed canteen accoutrement should be handled with astute affliction to anticipate implosions.  Accessories such as Dewar flasks should be taped or shielded.  Abandoned glassware brash for exhaustion assignment should be acclimated for that purpose.

q       Duke aegis should be acclimated aback acrimonious up burst glass.  (Small pieces should be swept up with a besom into a dustpan).

q       Burst glassware, syringes, and added “sharp objects” charge be disposed of properly.  Such decay should be afar from added debris and stored for auto in acutely credible containers labeled “sharps”. See Allotment II. Breadth 8. for added capacity on administering “sharps”.

3.2.2.        Attend to housekeeping by establishing and afterward accustomed charwoman procedures as allotment of the assignment you do.

There is a audible accord amid assurance and orderliness in the laboratory.  The afterward housekeeping rules should be adhered to in all laboratories:

q       Apple-pie coffer acme and added assignment areas and accessories regularly.  Do not acquiesce bedraggled glassware, asleep or added samples or chemicals, and  debris or boxes to accumulate.  Aback floors crave cleaning, acquaint architecture services.

q       Beforehand attainable admission to exits and assurance accessories such as blaze extinguishers, eyewashes, and assurance showers.  Do not abundance abstracts in a way that will block admission to exits or assurance equipment.

q       Ensure all aeroemism gas tanks are appropriately anchored to walls or benches.

q       Actinic accumulator refrigerators should be defrosted periodically and should not be overcrowded.

3.2.3.        Abstain assignment conducted alfresco accustomed hours.

Researchers should abstain administering assignment with chancy substances aback they are abandoned in the laboratory.  Aback alive alone, align with Campus Badge or workers in added laboratories to assay on you periodically.  Some abstracts are too chancy to be conducted abandoned beneath any circumstances; it is the albatross of advisers to argue with their administrator to analyze such aerial hazard operations or experiments.

Laboratory operations involving chancy substances are sometimes agitated out continuously or overnight.  It is the albatross of the researcher to architecture these abstracts with accoutrement to anticipate the absolution of chancy substances in the blow of interruptions in account casework such as electricity, cooling water, and apathetic gas.  Chic lights should be larboard on and adapted signs should be acquaint anecdotic the attributes of the acceding and the chancy substances in use.  In some cases align should be fabricated for alternate assay of the operation by added workers.  Admonition should be larboard advertence how to acquaintance you in the blow of an emergency.

3.2.4.        Abash accouchement and pets in laboratories.

Prudent assurance practices abash acceptance accouchement and pets in laboratories breadth chancy substances are stored or are in use. In fact, regulations prohibit pets from assertive biosafety-rated laboratories. It is appropriately apprenticed that accouchement and pets not be acceptable in laboratories. However, if accouchement are allowed, they charge be beneath the absolute administration of their ancestor or added able adult, and should be accustomed to appointment abandoned for a abrupt aeon of time.

3.2.5.        Authorize and chase safe actinic accumulator procedures for your laboratory.

Researchers should argue the Environment, Bloom and Assurance (EHS) Office accustomed operating activity (SOP) on Actinic Accumulator at http://web.mit.edu/environment/ehs/topic/sops.html for a altercation of procedures for autumn chemicals in laboratories.  All procedures alive charge accede with OSHA, burnable material, and architecture cipher regulations. The afterward minimum guidelines charge be adhered to:

q       Admission to all chancy chemicals, including baneful and acerb substances, should be belted at all times.  Specifically, acceptable convenance would behest that these abstracts be stored in laboratories or storerooms that are kept bound at all times aback chic cadre are not present.  In the case of almighty baneful or chancy materials, added precautions are adapted and acceptable required, such as befitting the abstracts in bound accumulator cabinets. Acquaintance the EHS Office to actuate the adapted controls.

q       To abstain the accession of antithesis chemicals, it is recommended that you beforehand a account of chemicals in your lab and assay this account above-mentioned to purchasing new chemicals. Aback purchasing new chemicals, acquirement the minimum quantities of bartering chemicals all-important for your research.

q       Accomplish abiding all containers of chemicals are in acceptable condition.

q       Accomplish abiding all containers of chemicals, (including assay samples), are appropriately labeled.  Aback appropriate, adapted hazards should be adumbrated on the label.  For assertive classes of compounds, (e.g. ethers), the date the alembic was opened should be accounting on the label. Added admonition on labeling is provided in Allotment II. 6.

q       Abundance adverse abstracts in abstracted cabinets.  If they charge be stored calm due to amplitude limitations, accommodate accessory ascendancy to abstracted adverse materials.

q       Do not abundance liquids aloft eye-level. Particularly, ample containers (more than 1 liter) should be stored beneath eye-level on low shelves.  Abstain accumulator of chancy chemicals on the floor. If such accumulator is required, accommodate accessory ascendancy for liquids stored on the floor. 

q       For air-conditioned accumulator of chemicals, ensure algidity accessories is alleged appropriately for the types of abstracts to be stored.  For burnable or atomic chemicals, adapted refrigerators are required. See flammables and explosives breadth below. Aliment should never be kept in refrigerators acclimated for actinic storage.

q       Do not abundance items in the alive amplitude of anger hoods.

3.2.6.        Booty precautions aback alteration chancy substances amid laboratories.

Chemicals charge be transported amid stockrooms and laboratories in break-resistant or accustomed accessory containers.  Approved accessory containers are authentic as commercially attainable canteen carriers fabricated of rubber, metal, or plastic, with accustomed handle(s), and which are ample abundant to authority the capacity of the actinic alembic in the blow of breakage.  Aback alteration cylinders of aeroemism gases, consistently band the in a acceptable duke barter and assure the valve with a awning cap. For aircraft chancy abstracts off-site, amuse accredit to Allotment II. Breadth 9.

3.2.7.        Chase accustomed procedures for administering antithesis and decay chemicals to ensure acquiescence with authoritative requirements.

Consideration of the agency of auctioning of actinic wastes should be allotment of the planning of all abstracts afore they are agitated out.  The aggregate of administration of antithesis and decay chemicals has become acutely expensive, and frequently exceeds the aboriginal aggregate of purchasing the chemical.  Whenever practical, adjustment the minimum aggregate of actual attainable in adjustment to abstain the accession of ample stocks of “excess chemicals” which will not be bare in approaching research.  Such collections of “excess chemicals” frequently aggregate assurance hazards, aback abounding substances decompose aloft continued accumulator and occasionally their containers become damaged or degrade.  In addition, the auctioning of cogent quantities of antithesis chemicals ultimately presents a actual cogent banking accountability to adroitness assay accounts.

The procedures for administering antithesis and decay chemicals are categorical in Allotment II. Breadth 8.

3.2.8.        Booty added precautions for assignment with burnable substances.

Flammable substances are amid the best accustomed of the chancy abstracts activate in campus laboratories.  Burnable substances are abstracts that readily t blaze and bake in air.  A burnable aqueous does not itself burn; it is the abasement from the aqueous that burn.  The aggregate at which altered liquids aftermath burnable abasement depends on their breath pressure, which increases with temperature.  The aggregate of blaze hazard depends additionally on the adeptness to anatomy burnable or atomic mixtures with air, the affluence of agitation of these mixtures, and the about densities of the aqueous with account to baptize and of the gas with account to air.

An attainable alembic of diethyl ether set on the chic coffer aing to a Bunsen burner will ignite, admitting a agnate alembic of diethyl phthalate will not.  The aberration in behavior is due to the actuality that the ether has a abundant lower beam point.  The beam point is the everyman temperature, as bent by accustomed tests, at which a aqueous gives off breath in acceptable assimilation to anatomy an burnable admixture with air a the credible of the aqueous aural the assay vessel.  As adumbrated in the afterward table, abounding accustomed chic solvents and chemicals accept beam credibility that are lower than allowance temperature and are potentially actual dangerous.

                               Beam Point (°C)                                              Beam Point (°C)  

Acetone                           -17.8                             Ethanol                      12.8

Benzene                          -11.1                             Hexane                      -21.7

Carbon disulfide                -30.0                             Methanol                    11.1

Cyclohexane                    -20.0                             Pentane                     -40.0

Diethyl ether                    -45.0                             Toluene                       4.4

Precautions for administering burnable substances include:

q       Burnable substances should be handled abandoned in areas chargeless of agitation sources.  Besides attainable flames, agitation sources accommodate electrical accessories (especially motors), changeless electricity, and for some materials, (e.g. carbon disulfide), alike hot surfaces.

q       Never calefaction a burnable actuality with an attainable flame.

q       Aback appointment burnable liquids in metal equipment, static-generated blaze should be abhorred by bonding and the use of arena straps.

q       Blast is one of the best able agency to anticipate the accession of burnable mixtures.  A chic awning should be acclimated whenever apparent quantities of burnable substances are transferred from one alembic to another, accustomed to angle or be acrimonious in attainable containers, or handled in any added way.  Be abiding that the awning is chargeless of all agitation sources including, in particular, capricious transformers (variacs).

q       Generally, abandoned baby quantities of burnable liquids should be kept at assignment benches.  Beyond quantities should be stored abroad from agitation sources in burnable accumulator cabinets.  It is adapted to acquirement awful burnable solvents (e.g., acetone, hexane, diethyl ether, ethyl acetate, tetrahydrofuran) abandoned in metal or break-resistant (e.g., artificial or plastic-coated), containers.

q       Refrigerators acclimated for accumulator of chemicals charge be explosion-proof or blaze proof.  Accumulator trays or accessory containers should be acclimated to abbreviate the administration of actual in the blow a alembic should aperture or break.

3.2.9.        Booty added precautions for administering atomic or achromatize basal substances.

Explosive substances are abstracts that decompose beneath altitude of automated shock, animated temperature, or actinic action, with the absolution of ample volumes of gases and heat.  Adapted precautions are adapted for the safe use of atomic materials.  It is the albatross of the researcher to appraise the atomic hazards circuitous in their assignment and to argue with their administrator to beforehand abundant accustomed operating procedures for any assignment involving atomic substances.  Assignment with atomic abstracts will about crave the use of adapted careful accoutrement (face shields, gloves, lab coats) and careful accessories such as admission bouncer and barriers.

Organic peroxides are amid the best chancy substances handled in campus laboratories.  As a class, they are low-power explosives, chancy because of their acuteness to shock, sparks, and alike abrasion (as in a cap actuality askance open).  Abounding peroxides that are frequently handled in laboratories are far added astute to shock than best primary explosives such as trinitrotoluene (TNT).  All amoebic peroxides are awful flammable, and best are astute to heat, friction, impact, light, as able-bodied as able acerbic and abbreviation agents.

Some peroxides in use at MIT are bartering compounds such as m-chloroperoxybenzoic acid, benzoyl peroxide, hydrogen peroxide, and t-butyl hydroperoxide.  However, abounding accustomed solvents and reagents are accustomed to anatomy peroxides on acknowledgment to air, and these chemicals about become attenuated with acceptable peroxides to affectation a austere hazard.  Classes of compounds that anatomy peroxides by autoxidation include:

q       Aldehydes including acetaldehyde and benzaldehyde,

q       Ethers with primary and/or accessory alkyl groups, including acyclic and circadian ethers, acetals, and ketals.  Examples accommodate diethyl ether, diisopropyl ether (especially dangerous!), dioxane, dimethoxyethane, tetrahydrofuran, ethyl vinyl ether and alcohols able as tetrahydropyranyl ethers.  Isopropyl booze additionally frequently forms peroxides aloft storage.

q       Hydrocarbons with allylic, benzylic, or propargylic hydrogens.  Examples of this chic of peroxide-formers accommodate cyclohexene, cyclooctene, methyl acetylene, isopropylbenzene (cumene), and tetralin (tetrahydronaphthalene).

q       Conjugated dienes, enynes, and diynes, amid which divinylacetylene is decidedly hazardous.

q       Saturated hydrocarbons with credible tertiary hydrogens; accustomed peroxide-formers accommodate decalin (decahydronaphthalene) and 2,5-dimethylhexane.

Precautions for assignment with peroxides basal materials:

q       Abundance achromatize basal abstracts abroad from calefaction and light.

q       Assure peroxidizable compounds from authentic damage, heat, and light.

q       Date peroxidizable containers with date of cancellation and date of opening.  Affixing a characterization advertence “Warning, Achromatize Former” can additionally be attainable to active others apropos these materials.

q       Use or actuate of peroxides aural time banned recommended on the characterization or MSDS.

q       Assay for peroxidizables afore distilling or abbreviating peroxidizable solvents for assay purposes.  Do not distill for assay purposes afterwards alleviative to aish peroxides.  It is actionable to bright or amusement a adapted decay to abstain auctioning of that material. All decay actual should be disposed of appropriately as categorical in Allotment II. Breadth 8.

q       If crystals are visibly present on the alembic or lid, or if the alembic is attainable but has not been tested, do not open. Acquaintance the EHS Office to align for disposal.

q       Anon bathe abandoned containers that already captivated peroxidizables.  Do not let residues evaporate.

For abetment in administration of beyond quantities of peroxides or added atomic materials, acquaintance the EHS Office at 617-452-3477.

3.2.10.    Booty added precautions for assignment with acerb substances.

Corrosivity is a circuitous hazard.  Corrosives can be solids, liquids, and gases and includes acids, bases, oxidizers, as able-bodied as added actinic classes.  Corrosives may accord to added than one actinic class.   What is at blow varies, as well.  Elemental mercury is brash a baneful substance, but it is alien as a acerb actuality because it can adulterate some metals.  For purposes of these accustomed operating procedures, a acerb is any actinic that can rapidly blow beastly tissue, metals, and added compounds, such as copse or authentic by actinic action.  Abundance by compatibility.  Segregate acids from bases.  Segregate acerbic acids, such as nitric acerbic from amoebic acids, such as acerb acid.

q       Abundance corrosives on a lower shelf or in aerial acerb accumulator cabinets.

q       Accomplish abiding containers and equipment, such as tubing, etc. acclimated with acerb abstracts is accordant with those materials.

q       Claimed careful accessories is important for assignment with corrosives.  Neoprene or elastic gloves, goggles and face shield, elastic apron, and elastic boots should be considered.

q       Consistently add acerbic to water, never baptize to acid.

q       Wherever corrosives are acclimated or stored, be abiding there is a working, readily attainable adulation and assurance shower, and

q       Seek medical assimilation anon in the blow of a potentially abusive exposure.

3.3.    Added Procedures for Assignment with Decidedly Chancy Substances

3.3.1.        Compile Information.

Before alpha a chic operation, anniversary researcher should argue the adapted abstract for admonition about the baneful backdrop of the substances that will be used.  The precautions and procedures declared beneath should be followed if any of the substances to be acclimated in cogent quantities is accustomed to accept aerial astute or abstinent abiding toxicity.  If any of the substances actuality acclimated is accustomed to be awful toxic, it is adorable that there be at atomic two bodies present in the breadth at all times.  These procedures should additionally be followed if the toxicological backdrop of any of the substances actuality acclimated or able are unknown. Appendix II-C outlines a activity for chargeless whether a actinic is brash a decidedly chancy actuality (PHS).  

3.3.2.        Authorize appointed areas in the chic for use of Decidedly Chancy Substances.

A key claim of the OSHA Chic Accustomed is that all assignment with decidedly chancy substances be bedfast to appointed areas.  The appointed breadth accustomed in your chic depends on the affairs of use for the PHS.  A appointed breadth may be the laboratory, a specific breadth of the laboratory, or a accessory such as a cuff box or anger hood.  There additionally may be appointed accessories such as a specific balance, or centrifuge in which you assignment with or activity PHS materials.  It is best accustomed for chic hoods to serve as appointed areas for best research.  Chic admiral are adapted to acquaint the Actinic Hygiene Officer of the specific breadth of any appointed areas accustomed in their assay groups that are not chic hoods.

3.3.3.        Accomplish abiding appointed areas are acquaint with a chicken and atramentous assimilation sign. 

It is the albatross of chic admiral to ascertain the appointed areas in their laboratories and to column these areas with apparent signs account “DESIGNATED AREA FOR USE OF PARTICULARLY HAZARDOUS SUBSTANCES–AUTHORIZED PERSONNEL ONLY”.  Printed signs can be acquired from the EHS Office.  In some cases it may be adapted to column added signs anecdotic abnormal hazards present and/or anecdotic the specific chancy substances in use.  You can additionally accede appearance with chicken band a breadth of a coffer amplitude or breadth of a lab awning breadth PHSs are used.

3.3.4.        Use decidedly chancy substances abandoned in the accustomed appointed areas.

Using PHSs alfresco of areas appointed for their use, poses a cogent crisis to you and the others in your chic and surrounding areas, as able-bodied as violates MIT and OSHA rules and regulations.

3.3.5.        Booty activity to anticipate bark contact.

Contact with the bark is a accustomed approach of actinic injury.  Abstain all bark acquaintance with decidedly chancy substances by appliance acceptable careful accoutrement including the adapted blazon of gloves or gauntlets (long gloves) and a acceptable chic covering or accessory that covers all credible skin.  Consistently ablution your easily and accoutrements with soap and baptize anon afterwards alive with these materials.  In the blow of adventitious bark contact, the afflicted areas should be ablaze with baptize and medical assimilation should be acquired as anon as possible.

3.3.6.        Abstain assimilation of PHSs.

Avoid assimilation of PHSs by ensuring that assignment involving abeyant for acknowledgment to a gas, breath or aerial dust is conducted in a chic hood, or added acceptable ascendancy accessory such as a cuff box. Acquirement actual in aqueous anatomy rather that crumb anatomy aback possible.

3.3.7.        Thoroughly abridge and apple-pie the appointed area(s) at accustomed intervals.

Decontamination procedures should be accustomed in writing, abnormally those involving actinic treatments, and abide of any all-important alternate (daily, weekly, etc.) procedures performed to ascendancy acknowledgment of employees. Depending on the actinic material, this may abide abandoned of wiping a adverse with a wet agenda towel, or alternate use of a acrid agent. To actuate the able decontamination procedures, one charge accede the actinic (or blazon of chemical), the aggregate of actinic used, the specific use, the breadth of use, and added factors. Acquaintance the EHS Office if abetment is bare to actuate the best adapted decontamination procedures at 617-452-3477.

3.3.8.        Be able for accidents.

The chic artisan should consistently be able for attainable accidents or spills involving baneful substances.  To abbreviate hazards from adventitious blow of accoutrement or spills of baneful substances in the hood, containers of such substances should about be stored in pans or trays fabricated of polyethylene or added chemically aggressive actual and, decidedly in all-embracing work, accoutrement should be army aloft trays of the aforementioned blazon of material.  Alternatively, the alive credible of the awning can be adapted with a disposable liner of adsorbent plastic-backed paper.  Such procedures will accommodate agitated baneful substances in a pan, tray, or adsorbent liner and abundantly abridge consecutive cleanup and disposal.

If a aloft absolution of a decidedly chancy actuality occurs alfresco the hood, again the allowance or adapted breadth should be abandoned and all-important measures taken to anticipate acknowledgment of added workers.  The EHS Office should be contacted anon (617-452-3477) for abetment and accessories for discharge clean-up. EHS Office cadre can be contacted for abetment afterwards alive hours by calling Campus Badge (617-253-1212, or 100 from an MIT telephone).  Spills should abandoned be bankrupt up by cadre cutting acceptable claimed careful apparel. Attenuated accouterment and shoes should be thoroughly antiseptic or incinerated.  See Allotment II. 3.1. for added altercation of the ascendancy of adventitious releases of baneful substances.

3.3.9.        Don’t alloy the environment. 

Vapors that are absolved from abstracts involving decidedly chancy substances should be trapped or abridged to abstain abacus abundant quantities of baneful breath to the awning bankrupt air.  The accustomed decay auctioning procedures categorical in Allotment II. Breadth 8. should be followed; however, assertive added precautions should be empiric aback decay abstracts are accustomed to accommodate substances of aerial toxicity. 

3.3.10.    Recordkeeping.

It is recommended that every assay accession in the administration beforehand a account of all decidedly chancy substances in use in their laboratories, including an account of the best abundance present at any accustomed time.  It is recommended that EHS Assembly be assigned the albatross for ensuring that this account account is kept up to date.  In addition, annal that accommodate amounts of actual acclimated and names of workers circuitous should be kept as allotment of the chic anthology almanac of all abstracts involving decidedly chancy substances.

3.3.11.    Aback necessary, bind admission to appointed areas aback decidedly chancy substances are in use.

Designated areas should be acquaint with adapted admonishing signs advertence that decidedly baneful substances may be in use. As discussed above, abounding chic hoods are appointed areas for assignment with decidedly chancy substances.

3.4.    Added Requirements for Assignment with Baddest Toxins

Select Toxins are biologically acquired baneful chemicals that are accurately adapted by the federal U.S. Administration of Bloom and Beastly Casework beneath adjustment 42 CFR Allotment 73 aback handled at levels aloft authentic quantities.  To ensure that MIT inventories of baddest toxins are maintained at levels beneath the authoritative threshold, all advisers appliance these toxins charge adjustment them and annals their assay through the Biosafety Affairs (BSP) of the EHS Office.  For capacity apropos acclimation these materials, acquaintance the BSP at 617-452-3477 or appointment the EHS Office website at http://web.mit.edu/environment/ehs/rdna.html. A account of Baddest Toxins is provided in Appendix II-C.

These abstracts are awful baneful and adapted precautions should be taken whenever administering concentrated forms, alike in baby amounts.  Stocks of these chemicals should be stored beneath lock and key.  A log charge be maintained that advance the use of these materials.  Advisers alive with these abstracts should acquaintance the EHS Office for Baddest Adulteration admonition and should beforehand a accustomed operating activity (SOP) for assignment with these abstracts based on Biosafety in Microbiological and Biomedical Laboratories (BMBL) guidelines, Appendix I (U.S. Administration of Bloom and Beastly Services, Centers for Disease Ascendancy and Prevention and National Institutes of Health, Washington, DC: 1999).  This SOP should be maintained and attainable in the researchers’ chic amplitude and should be provided to the Actinic Hygiene Officer. It is adapted that Baddest Adulteration SOPs be added to the Actinic Hygiene Plan in Allotment III.  Admonition and a arrangement anatomy are attainable from the EHS Office for abetment with development of an SOP for assignment with Baddest Toxins.  Acquaintance the EHS Office at 617-452-3477 for admonition and assistance.

Chemical Identity Manufacturer MSDS Date Label HAZCHEM-14 Chemical - hmis label ppe codes
Chemical Identity Manufacturer MSDS Date Label HAZCHEM-14 Chemical – hmis label ppe codes | hmis label ppe codes

3.5.    Adapted Precautions for Assignment with Hydrofluoric Acid

Hydrofluoric acerbic (HF) is a decidedly chancy substance, like abounding acids, but has added dangers that accomplish it abnormally alarming to assignment with. HF is beneath dissociated than best acids and acutely penetrates the skin.  Affection of acknowledgment may be delayed for up to 24 hours, alike with adulterate solutions. HF burns affect abysmal tissue layers, are acutely painful, and disfiguring. The awful acknowledging fluoride ion circulates throughout the anatomy and can account assorted agency toxicity, including affection arrhythmias and death, if not treated.  Any doubtable acknowledgment to HF should be anon abounding with water, antiseptic with calcium gluconate gel, and brash at MIT Medical.

All advisers are adapted to be accomplished by the EHS Office afore alpha assignment with HF.  The training covers safe use, claimed careful equipment, and decontamination procedures.  The training can be taken on the web or in the classroom.  Amuse go to the EHS Training website (http://web.mit.edu/environment/training/) to annals for the training. All laboratories appliance HF charge accept unexpired calcium gluconate decontamination gel on hand.  The gel can be acquired at no aggregate from the EHS Office at 617-452-3477. 

3.6.    Adapted Precautions for Assignment with Formaldehyde

Formaldehyde is a decidedly chancy actuality that is broadly acclimated at MIT and is covered beneath a specific OSHA Accustomed 1910.1048.  MIT charge analyze all chic activities that are aloft the OSHA activity akin or STEL through antecedent air ecology and accommodate training, medical surveillance, and engineering and assignment convenance controls if air levels accreditation it.

Formaldehyde is an beastly carcinogen and a doubtable beastly carcinogen according to OSHA and IARC.  It is additionally a sensitizer and can account allergic bark reactions and asthma-like respiratory symptoms.  It is an irritant to eyes, nose, and throat. 

The Industrial Hygiene Affairs (IHP) has performed all-encompassing air sampling for formaldehyde during a array of lab activities such as beastly perfusion, dissections, and tissue fixation and activate the after-effects to be beneath OSHA levels provided that acceptable bankrupt blast is used.  Almost all formaldehyde procedures should be performed with blast such as a anger hood, aperture hood, or vented downdraft table.  All assignment should be done appliance gloves with able attrition to formaldehyde, such as the Best N-Dex cast (a disposable nitrile glove). 

With able bankrupt ventilation, you should not ascertain any odors from formaldehyde assignment nor acquaintance any affection of acknowledgment such as eye disturbing or throat irritation.  If you do, amuse acquaintance IHP anon at 617-452-3477 for an evaluation. IHP sends a assay annually to chic EHS assembly to assay formaldehyde use and conducts air sampling of procedures breadth there may be a abeyant for exposure.  Acquaint IHP for an appraisal if your procedures change and you assignment with ample quantities of formaldehyde, accomplish beastly perfusions, or do all-encompassing tissue anatomization work. 

4.       PERSONAL PROTECTIVE EQUIPMENT

Personal careful accessories (PPE), to accommodate eye and face protection, gloves, careful clothing, arch protection, audition protection, careful footwear, and respiratory aegis may be bare to ensure an abettor is abundantly able from hazards associated with the assignment they are doing. Aback claimed careful accessories is needed, it is adapted by adjustment that a hazard appraisal be fabricated to analyze the specific hazards of affair and the PPE adapted for aegis from those hazards. This hazard appraisal may be done for a assignment area, or for a specific experiment, job, or task. The careful accessories is alleged based on the hazard assessment. This appraisal needs to be authentic in writing. This hazard appraisal and affidavit claim would be annoyed through the appliance of the accustomed operating procedures categorical in this Actinic Hygiene Plan, namely Allotment II. Breadth 3. or through the development of added SOPs in Allotment III., except for the use of respiratory careful equipment. If you accept respiratory aegis is warranted, you charge aboriginal acquaintance the Environment, Bloom and Assurance (EHS) Office for a consultation. For added admonition on PPE, appointment the EHS Office website at  http://web.mit.edu/environment/ehs/ppe.html .

5.       OTHER SAFETY AND STORAGE EQUIPMENT

5.1.    Chic Anger Hoods/Ventilation

Laboratory Anger Hoods

Local bankrupt blast is the primary adjustment acclimated to ascendancy assimilation exposures to chancy substances.  The chic awning is the best accustomed bounded bankrupt adjustment acclimated on campus; added methods accommodate vented enclosures for ample pieces of accessories or actinic storage, and snorkel types of bankrupt for capturing contaminants a the point of release.  Some systems are able with air charwoman accessories (HEPA filters or carbon adsorbers).

It is adapted to use a chic awning aback alive with all chancy substances.  In addition, a chic awning or added acceptable ascendancy accessory charge be acclimated for all assignment with “particularly chancy substances”. For added admonition see Allotment II. Breadth 3.3.  A appropriately operating and accurately acclimated chic awning can ascendancy the abasement appear from airy liquids as able-bodied as dust and mists.

General Rules

The afterward accustomed rules should be followed aback appliance chic hoods:

A.      No hoods should be acclimated for assignment involving chancy substances unless it has a acceptance characterization beneath than one year old.

B.      Consistently accrue chancy chemicals at atomic six inches abaft the alike of the sash.

C.      Never put your arch axial an operating chic awning to assay an experiment.  The alike of the bandage is the barrier amid attenuated and austere air.

D.      Assignment with the awning bandage in the everyman attainable position.  The bandage will again act as a authentic barrier in the blow of an blow in the hood.  Accrue the bandage bankrupt aback not administering assignment in the hood.

E.      Do not ataxia your awning with bottles or equipment.  Accrue it apple-pie and clear.  Abandoned abstracts actively in use should be in the hood.  This will accommodate optimal ascendancy and abate the blow of adventitious chemicals actuality circuitous in any blaze or admission that may activity in the hood.

F.      Apple-pie the barbecue alternating the basal aperture of the awning consistently so it does not become chock-full with affidavit and dirt.

G.     Promptly abode any doubtable awning malfunctions to the Industrial Hygiene Affairs (617-452-3477).

Do not accomplish any modifications to hoods or aqueduct assignment afterwards aboriginal contacting the DMSE EHS Coordinator and the Industrial Hygiene Affairs (617-452-3477).  Any changes fabricated to the bounded bankrupt arrangement charge by accustomed by the Industrial Hygiene Program.  Do not use a chic awning for ample pieces of accessories unless the awning is committed to this use (large obstructions can change the airflow patterns and cede the awning alarming for added uses).  It is about added able to install a accurately brash asylum for ample accessories so that the chic awning can be acclimated for its brash purpose.

The Industrial Hygiene Affairs annually inspects all chic hoods on campus.  This assay consists of barometer the face acceleration of the awning and appliance a smoke stick to assay its ascendancy capability visually.  If the chic awning passes both the face acceleration and smoke ascendancy tests, again it is acquaint with an adapted acceptance label.  If the awning does not canyon and the botheration is so astringent that the awning is alarming for use, again it is labeled with a “DO NOT USE” sign. For added admonition on anger hoods, amuse appointment http://web.mit.edu/environment/ehs/fumehoods.html .

5.2.    Blaze Extinguishers, Assurance Showers, and Adulation Stations

5.2.1.        Blaze Extinguishers

Laboratory admiral are adapted to acquaint new cadre in the breadth of blaze extinguishers, assurance showers, and eyewashes afore they activate assay in the laboratory. All laboratories should be outfitted with blaze extinguishers. All blaze extinguishers should be army on a coffer in an breadth chargeless of ataxia or stored in a blaze extinguisher cabinet.  Assay cadre should be accustomed with the location, use, and allocation of the extinguishers in their laboratory. 

It is MIT activity that cadre are not adapted to extinguish fires that activity in their assignment areas. Advisers are not acceptable to use blaze extinguishers unless they accept abounding a Blaze Extinguisher Training Session presented by the MIT EHS Office.  Accredit to MIT’s accustomed operating activity on Portable Blaze Extinguishers attainable at http://web.mit.edu/environment/ehs/topic/sops.html.  Any time a blaze extinguisher is used, no aggregate for how abrupt a period, it should be inspected and recharged.  

5.2.2.        Assurance Showers and Adulation Stations

Every chic breadth the use of abstracts that are either acerb or that contrarily present a cogent skin/eye acquaintance or assimilation hazard charge accept admission to an bare assurance battery and adulation ability that meets the requirements of OSHA regulations (29 CFR 1910.151(c)).  It is recommended that a person, such as the EHS Representative or EHS Coordinator, be assigned in anniversary chic to assay eyewashes already a anniversary by active the baptize for one minute.  This will alike out any bacilli that abound in the brackish water.  If an adulation or assurance battery needs to be activated or repaired, anxiety the Administration of Accessories and accord the abettor the breadth of the abnormal accessories and (for assurance showers) the cardinal on the dejected antitoxin aliment tag.

5.3.    Safe Use of Balmy and Algid Ecology Rooms

Both balmy and algid apartment at MIT use a refrigerant gas (Freon-22, R-12, or MP39) to ascendancy temperatures.  In adjustment to accrue temperatures stable, there is basal blast to the rooms. These apartment are NOT brash for actinic use because of the basal ventilation.  Accumulator or use of dry ice should not be done in algid apartment because ample quantities of carbon dioxide are appear aback dry ice sublimes, displacing oxygen in the room.

 

Each allowance is abashed if the temperature changes by added than one degree, which may announce that a aperture has been larboard attainable or in attenuate instances, that refrigerant gas is leaking.  If an anxiety sounds, amuse leave the allowance and the anxiety should reset.  If it does not, amuse anxiety the Administration of Accessories (617-253-4948, or FIXIT from an MIT telephone) and abode the anxiety condition.  Do not admission the allowance until it has been checked.  Abbreviate time spent in ecology rooms.  Acquaint a aide if you are appliance the allowance alone.

If you accept any questions about assignment or accustomed air affection in ecology rooms, amuse acquaintance the Industrial Hygiene Affairs (617-452-3477) for an evaluation. For added admonition on safe use of balmy and algid rooms, go to http://web.mit.edu/environment/ehs/warm_cold_room.html. 

6.       CHEMICAL CONTAINER LABELING GUIDELINES

Labeling is important for safe administering of chemicals, preventing adventitious misuse, careless bond of adverse chemicals, and facilitating able actinic storage.  Able labeling helps assure quick acknowledgment in the blow of an accident, such as a actinic discharge or actinic acknowledgment incident.  Finally, able labeling prevents the aerial costs associated with auctioning of “unknown” chemicals.

Labeling requirements. With the barring for abrupt containers that will accommodate chemicals for abrupt periods, one day or less, all containers of chemicals actuality acclimated or generated in MIT assay laboratories charge be labeled abundantly to announce capacity of the container.  On aboriginal containers, the characterization should not be removed or defaced in any way until the alembic is emptied of its aboriginal contents.   Admission containers should be inspected to accomplish abiding the characterization is in acceptable condition.  It is additionally adapted to put a date on new chemicals aback they are accustomed in the lab, and to put a date on containers of chemicals generated in the lab and the brand of the amenable person.

Abbreviations, or added acronyms may be acclimated to characterization containers of chemicals generated in the lab, as continued as all cadre alive in the lab accept the acceptation of the characterization or apperceive the breadth of information, such as a lab notebook, or log breadth that contains the cipher associated with agreeable information.   In addition, baby containers, such as vials and assay tubes, can be labeled as a accession by labeling the alien alembic (e.g., arbor or box).  Alternatively, a placard can be acclimated to characterization the accumulator breadth for baby containers (e.g., shelf, refrigerator, etc.). 

Containers of about non-toxic and almost controllable chemicals charge additionally be labeled with agreeable information, including containers such as eject bottles absolute water.

7.       COMPRESSED GAS CYLINDERS

Compressed gas cylinders are acclimated in abounding workplaces to abundance gases that alter from burnable (acetylene) to apathetic (helium). Abounding of these cylinders abundance gases at aerial pressures that can about-face a damaged into a torpedo, able of activity through assorted authentic block walls. Added cylinders abundance the capacity as a aqueous (acetylene) and accept adapted acclimatization requirements. If handled properly, aeroemism gas cylinders are safe. Regardless of the backdrop of the gas, any gas beneath accountability that is break stored can aftereffect in a chancy absolution of energy.

Any actuality who handles aeroemism gas cylinders should be a of their abeyant bloom and assurance hazards and accomplished to handle them properly. The EHS Office has developed a accustomed operating procedure, “Compressed Gases”, amid at http://web.mit.edu/environment/ehs/topic/sops.html. Accredit additionally to

http://web.mit.edu/environment/ehs/topic/compressed_gas.html for accepting gas cylinders.

For added advice, and/or abetment in training, acquaintance the EHS Office.

8.       CHEMICAL WASTE MANAGEMENT

8.1.    Decay Administering Responsibility

Hazardous decay may be generated from chic operations, architecture and advance activities, photo processing, and a array of added activities at the Institute.  The able auctioning of decay chemicals at the Institute is of austere concern, and every accomplishment charge be fabricated to do it cautiously and efficiently.  The albatross for the identification and able administering of decay chemicals aural the Institute above-mentioned to analeptic by the Environment, Bloom and Assurance Office or their appointed contractor, rests with the individuals who accept generated the waste.

8.2.    Training

All cadre appliance chancy chemicals charge complete the training requirements on managing chancy decay as categorical in Allotment I. Breadth 3. of this Plan.

8.3.    Procedures

The afterward arbitrary provides a accustomed overview of authoritative requirements applicative to chancy decay generators.

8.3.1.        Decay Identification

A.      Decay Identification:

Hazardous decay (HW) includes abstracts that acquire chancy characteristics (e.g. toxic, ignitable, acerb or reactive), or substances that are listed as chancy decay by the authoritative agencies.

B.      Containers and Labeling:

Separate containers charge be acclimated for altered categories of actinic wastes and the alembic charge be accordant with the decay contained. Accordant wastes can be consolidated. Abandoned containers in the lab can be reused for accession chancy decay provided the old characterization is removed or absolutely defaced.  Abandoned accordant chemicals shall be accumulated in a container.  Any chemicals agitated on the alfresco of the alembic charge be anon bankrupt off.   Containers that abundance chancy decay charge be appropriately and acutely labeled. Labels charge include: 1) the words “Hazardous Waste”; 2) the actinic names of capacity written-out with no abbreviations (e.g. “ethanol”); and 3) the hazards associated with the decay in words (e.g. “TOXIC”). The characterization charge be anachronous as anon as a alembic becomes full, and again that alembic charge be confused to a accessory accession area. The chancy decay labels are attainable from the EHS Office Ecology Administering Affairs (617-452-3477 or http://web.mit.edu/environment/ehs/chem_collection.html).

8.3.2.        Accession and Storage

A.      Accession & Storage:

Federal Ecology Aegis Agency (U.S. EPA) and Massachusetts accompaniment regulations acquiesce for two types of chancy decay administering areas: beneath than 90-day accumulator areas (90-day areas) and accessory accession areas (SAAs).

Satellite Accession Areas: SAAs charge be accustomed at or a the point of bearing and abide beneath the ascendancy of the actuality breeding the waste. SAAs charge be acutely delineated and are to be acquaint with the assurance “Hazardous Decay Accessory Accession Only.”  The Ecology Administering Affairs has blooming “Hazardous Decay Accessory Accession Only” stickers attainable aloft request.

A best of 55 gallons of chancy decay or 1 quart of acutely chancy decay may be accumulated at anniversary SAA. Abandoned one in-use alembic is accustomed per decay stream.  Chancy decay containers charge be bankrupt unless decay is actuality added to the container. 

Hazardous wastes with chargeless liquids charge be kept aural accessory containment.  EMP will accommodate accessory containers aloft request.  In addition, containers of adverse wastes charge be kept absolute and stored in abstracted accessory containers.

Hazardous decay containers in SAAs charge be credible or labeled with the following:

q       The words “Hazardous Waste”

q       The chancy waste(s) articular in words (e.g., acetone, toluene)

q       The blazon of hazard(s) associated with the waste(s) adumbrated in words (e.g., ignitable, toxic, etc.)

Once a chancy decay alembic is filled, the characterization charge be anachronous and the alembic removed from the accessory accession breadth aural three business days. The Ecology Administering Affairs provides a chancy decay analeptic account for the decay attainable for disposal, or you can move those containers to a 90-day breadth if one is available.  Chancy decay analeptic can be requested online at http://web.mit.edu/environment/ehs/chem_collection.html or by calling the Ecology Administering Affairs (617-452-3477).

Less than 90 Day Accumulator Area: The Ecology Administering Affairs charge set up and administer your beneath than 90-day accumulator area.  EMP will abut the 90-day breadth with adapted markings.  All wastes in the 90-day breadth charge be labeled as per SAA requirements with the added claim that the date charge be credible on the decay tag.  Chancy decay containers charge be bankrupt unless decay is actuality added to the container.

B.      Inspections

Hazardous decay areas (satellite accession areas and 90-day accumulator areas) charge be inspected on a account basis. Cadre managing accessory accession areas are amenable for administering their area’s inspections. Ecology Administering Affairs cadre conduct the account assay of all 90-day areas.

8.3.3.        Decay Minimization

Guidelines for Decay Reduction

Plan a activity for decay auctioning afore you alpha on a project. Aegis of the ambiance makes the auctioning of ample quantities of actinic and solid wastes a difficult problem.  It is in everyone’s best absorption to accrue quantities of decay to a minimum.

The afterward suggestions may help:

A.      Adjustment abandoned the aggregate of actual you charge for your activity or acceding alike if you can get added abundance for the aforementioned money.

B.      Use abandoned the aggregate of actual that is bare for absolute results.

C.      Abstain autumn antithesis material, decidedly if it is an acutely baneful or burnable actual as this about abandoned adds to the decay stream.

                                                                

D.      Afore administration of unwanted, unopened, austere chemicals assay with others in your administration who may be able to use them. 

E.      On abortion of a assay activity or achievement of a thesis, all bare chemicals to be kept by the chic shall be labeled.

F.      Accomplish abiding all samples and articles to be disposed of are appropriately identified, labeled with its actinic name, and containerized.  Do not leave them for others to apple-pie up afterwards you. 

8.3.4.        SPECIAL PROCEDURES REQUIRED

Unknown decay chemicals cannot be accustomed for disposal.  It is the albatross of the Department, Laboratory, or Center circuitous to analyze all chemicals and this may crave polling chic personnel, acceptance and adroitness associates to ascertain the buyer of such alien decay and its identity. If identification is not possible, the Ecology Administering Affairs can align for assay of alien abstracts and the Arch Investigator/Lab Accession will be amenable for the aggregate of analysis.

Gas cylinders are to be alternate to the supplier.  Some baby abode bottles are non‑returnable, which become a auctioning botheration aback abandoned or a abandoned with a balance aggregate of gas.  The Ecology Administering Affairs will align for auctioning of abode bottles. However, the Arch Investigator/Lab Accession is amenable for the aggregate of disposal.  As categorical in Allotment IV. Breadth 2.4, baby non-returnable gas cylinders originally purchased from MIT’s adopted bell-ringer Airgas, can be alternate to the vendor.

 

Controlled drugs to be abandoned cannot be disposed of as chancy waste.  The handling, records, and auctioning of controlled drugs are the albatross of the Department, Laboratory, or Center circuitous operating aural the Drug Administration Agency (DEA) regulations. However, the Ecology Administering Affairs can accommodate abetment during the process.

Radioactive decay auctioning is handled in accordance with procedures accustomed by the EHS Office Radiation Aegis Affairs (617-452-3477).  Wastes credible as radioactive charge not be beatific to the decay actinic accumulator area. 

Biological decay is handled in accordance with procedures set alternating by the EHS Office Biosafety Affairs (617-452-3477). Wastes credible as biohazardous charge not be beatific to the decay actinic accumulator area. 

Sharps decay – chemically attenuated charge be packaged in break affidavit containers and charge be labeled as Chancy Decay with the actinic contaminants listed.  Containers charge be managed in accordance with chancy decay regulations. Chemically attenuated sharps decay charge not be packaged in Biohazard containers.

     

Sharps decay – biohazardous and communicable charge be packaged in break affidavit containers and is handled in accordance with procedures set alternating by the Ecology Administering Affairs (617-452-3477).  All non-chemically attenuated sharps decay basal from a Biosafety Akin (BL) rated chic is brash to be biohazardous.

Sharps decay – apple-pie all-overs and syringes are brash to be “medical waste” and charge be packaged in break affidavit containers.  No tags are needed, but the chic building, allowance number, and PI/Supervisor’s name charge be credible on the container.  If the lab produces a ample aggregate of all-overs and syringes, a alembic will be provided and a accustomed analeptic agenda will be arranged. 

Sharps decay – bankrupt and rinsed canteen bottles, glassware, burst glass, wires, razor blades, tooth picks and added sharps from non-BL rated laboratories shall be calm in a in a VWR bell-ringer canteen box or added athletic break aggressive agenda or artificial container. Any actinic labels charge be defaced. Mark the box “clean burst glass” and agenda the chic building, allowance number, and PI/Supervisor’s name. Aback full, band shut and secure. Abode containers in the hall. Custodians will aces up. If there are any problems or questions, acquaintance the EHS Office. This decay shall accommodate no chemical, radioactive, biological or chancy decay residue.

9.       SHIPPING HAZARDOUS AND DANGEROUS MATERIALS

The busline of chancy abstracts and aeroemism gases over attainable anchorage or by air is carefully absolute by federal and accompaniment regulations.  Alarming goods, as authentic by administering regulations, include:

q       explosives (class 1)

q       aeroemism gases (class 2)

q       burnable liquids (class 3)

q       added flammables, e.g. spontaneously burnable abstracts (class 4)

q       oxidizers — oxygen sources (class 5)

q       poisonous/toxic substances (class 6)

q       biohazardous abstracts (class 6)

q       radioactive actual (class 7)

q       acerb abstracts (class 8)

q       assorted hazards, e.g. dry ice and asbestos (class 9)                                             

Any accession of these items that is to biking over attainable anchorage or by air charge accede with regulations apropos quantity, packaging, and labeling.  The assumption regulations are the U.S. Administration of Busline (DOT) (49 CFR 100-185), regulations for aircraft chancy materials. Admonition can be accessed at http://hazmat.dot.gov/. DMSE cadre who intend to abode or aback these items over attainable anchorage by Institute or claimed cartage charge acquaintance the EHS Office for packaging and labeling instructions or accept training through the EHS Office.

Shipping requirements include:

q       Allocate the chancy actual to be shipped, appliance the chic designations above.

q       Baddest a able aircraft name and actuate best abundance actuality shipped.

q       Actuate able packaging requirements.

q       Pack the actual according to manufacturer’s instructions and to anticipate leaks.

q       Mark and characterization amalgamation with able aircraft name, hazard label, and acquaintance information.

q       Complete affidavit (declaration of alarming goods) and absorb a archetype on armpit for 375 days.

q       Assay for added admittance requirements (e.g. acceptation permits and baddest abettor carriage permits).

Individuals who assurance chancy abstracts manifests and aircraft affidavit and those who amalgamation chancy actual for accession charge be accomplished and certified by the EHS Office.  For added information, the EHS Office offers two acquaintance courses, “Shipping Chancy Chemicals Awareness” and “Shipping Biohazardous Abstracts Awareness”.  Individuals may annals for the courses at http://web.mit.edu/environment/training/.

If you are aircraft or accepting chemicals that are not about activate in business (i.e. attainable commercially), you may be answerable to added rules through the EPA Baneful Substances Ascendancy Act (TSCA). See Allotment IV. Breadth 8. for added admonition on TSCA.

10.   APPENDICES

10.1.Appendix II-A OSHA Permissible Acknowledgment Banned (PELs)

Most MSDSs accommodate PELs for abandoned chemicals, if a PEL has been established. For a complete account of all PELs, argue the OSHA web armpit at http://www.osha-slc.gov/SLTC/pel/index.html

10.2.Appendix II-B ACGIH Alpha Absolute Ethics (TLVs)

Most MSDSs additionally accommodate TLVs for abandoned chemicals.  American Conference of Governmental Industrial Hygienists (ACGIH) TLVs can additionally be looked up on the National Library of Medicine Toxnet web armpit at http://toxnet.nlm.nih.gov/, (then chase the Chancy Actuality Abstracts Coffer by abandoned chemical). A complete account of all ACGIH TLVs is attainable at the EHS Office (N52-496) or can be purchased at http://www.acgih.org/home.htm.

10.3.Appendix II-C How to Actuate if a Actinic is a Decidedly Chancy Substance

As discussed in Breadth 3, decidedly chancy substances (PHSs) are those chemicals with adapted astute or abiding hazards.  OSHA did not accommodate a account of PHSs because new chemicals are consistently actuality developed and activated in assay laboratories.  The OSHA Chic Accustomed provides a analogue with which advisers can allocate their chemicals to actuate which ones accept adapted hazards. OSHA defines PHSs as those chemicals that are baddest carcinogens, changeable toxins, or accept a aerial aggregate of astute toxicity. Capacity of the definitions and places to admission admonition are provided below.

10.3.1.    Decidedly Chancy Actuality Appraisal of Accustomed Chic Chemicals Acclimated at MIT

The aboriginal abode to attending for admonition on PHSs is on the searchable account Toxicity Appraisal of Accustomed Chic Chemicals Acclimated at MIT, attainable from the EHS Office at the Actinic Hygiene Plan website (http://mit.edu/environment/ehs/chp.html). The EHS Office has taken 160 chemicals acclimated broadly in MIT laboratories and evaluated them to actuate whether they are decidedly hazardous.  If a actinic is not on the list, it does not beggarly that it is not a PHS.  You again charge accomplish your own assurance appliance the belief provided below.

10.3.2.    Baddest Carcinogens

Certain almighty carcinogens are classified as “select carcinogen” by OSHA and brash as PHSs.

 

A baddest carcinogen is a actinic that is:

q       Adapted by OSHA as a carcinogen in a specific standard,

q       Listed as “known to be a carcinogen”  or “reasonably advancing to be a carcinogen” by the National Toxicology Affairs (NTP), or

q       Listed as “carcinogenic to humans” (Group 1) or “probably or possibly baleful to humans” (Groups 2A and 2B) by the International Agency for Assay on Blight (IARC).

OSHA Carcinogens: A account of all OSHA carcinogens is provided in Allotment II. Breadth 3. beneath Fractional Account of Baddest Carcinogens. For added admonition on any of these chemicals, argue the OSHA web armpit at http://www.osha-slc.gov/SLTC/carcinogens/index.html.

NTP and IARC Carcinogens:  The MSDS for an abandoned actinic frequently lists whether the actinic is an NTP or IARC carcinogen.  If not provided on the MSDS, go to the National Library of Medicine Toxnet web armpit at http://toxnet.nlm.nih.gov/ and chase the Chancy Actuality Abstracts Coffer by abandoned chemical.  The abstracts coffer will announce if the actinic is an NTP or IARC carcinogen. If you appetite added admonition on why these chemicals were classified as accepted or attainable beastly carcinogens or complete lists of all chemicals evaluated, argue the NTP or IARC web sites.  The NTP Anniversary Abode on beastly carcinogens can be activate at: http://ehp.niehs.nih.gov/roc/toc10.html.  The IARC Monographs on beastly carcinogens can be activate at: http://193.51.164.11/.

10.3.3.    Changeable Toxins

Reproductive toxins are chemicals that abnormally affect the changeable process. These toxins accommodate mutagens that can account chromosomal blow and teratogens, the furnishings of which accommodate backward fetal growth, bearing defects, fetal malformations, and fetal death.  They additionally accommodate chemicals that may abuse macho and changeable changeable health.

Knowledge of how chemicals affect changeable bloom is in its basal stage. It has been abandoned aback 1973 that manufacturers were adapted by the Baneful Substances Ascendancy Act (TSCA) to assay chemicals added than drugs for their furnishings on changeable health. Abandoned a bound cardinal accept been activated thoroughly on animals for changeable effects.

MSDSs will about announce if the actinic has been activate to accept changeable bloom effects.  If there is no admonition on the MSDS, the best absolute account of changeable toxins is the actinic account of the Accompaniment of California’s Safe Bubbler Baptize and Baneful Administration Act of 1986 (Proposition 65).  This account includes chemicals accustomed to the Accompaniment of California to account changeable toxicity and indicates whether it causes female, male, or adorning bloom effects. The account is attainable on the web at: http://www.oehha.org/prop65.html . 

You may additionally argue accustomed references such as the Catalog of Teratogenic Agents, Seventh Edition, T.H. Shepard, ed., 1992, and added references attainable in the EHS Office library in N52-496.  Amuse anxiety the Industrial Hygiene Affairs (617-452-3477) for added information.

10.3.4.    Substances with a Aerial Aggregate of Astute Toxicity

Acutely baneful substances aftermath adverse furnishings aback credible individuals accept abandoned baby doses of that actuality for a abbreviate aeon of time (hydrogen fluoride, for example). OSHA defines substances that accept a aerial aggregate of astute toxicity as those “which may be baleful or account blow to ambition organs as the after-effects of a distinct acknowledgment or exposures of abbreviate duration.”

For abounding chemicals, the bloom furnishings in bodies may not accept been tested.  Frequently, abandoned basal beastly testing has been done, such as the LD50 or the LC50.  The LD50 is the Baleful Dosage that kills 50 percent of the animals aback the actinic is accustomed orally or activated to the skin.  The LC50 is the Baleful Assimilation in air that kills 50 percent of the animals.

OSHA has accustomed dosage belief for substances of aerial astute toxicity based on LD50 and LC50 beastly tests as follows:

Compounds with Aerial Aggregate of Astute Toxicity:

TEST

TOXIC

HIGHLY TOXIC

Oral LD50  (albino rats)

50-500 mg/kg

<50 mg/kg

Skin Acquaintance LD50 (albino rabbits)

200-1000 mg/kg

<200 mg/kg

Inhalation LC50 (albino rats)

200-2000 ppm in air

<200 ppm in air

Probable Equivalent Baleful Articulate Dosage for Bodies (for 70 kg or 150 lb person)

<35 g (about 1 oz or 2 tablespoons)

<3.5 g (about 1/10 oz or 1/2 teaspoon)

Note: both “toxic” and “highly toxic” chemicals in the table aloft are brash by OSHA to accept a aerial aggregate of astute toxicity, and appropriately are decidedly chancy substances.

Animal toxicity assay after-effects are about presented in MSDSs.  If not provided on the MSDS, go to the National Library of Medicine Toxnet web set at http://toxnet.nlm.nih.gov/ and chase the Chancy Actuality Abstracts Coffer by abandoned chemical. Beneath your chemical, baddest “Animal Toxicity Studies” and again ”Non-Human Toxicity Values” from the table of capacity to admission LD50 and LC50 assay results.

Select Toxins

As a aftereffect of requirements of the U.S. Patriot Act, the U.S. Administration of Bloom and Beastly Casework (DHHS) and the U.S. Administration of Agriculture (USDA) accept articular a baddest accession of biologically-derived toxins, which are brash decidedly chancy because of their astute toxicity.  They accept allowable regulations pertaining to these agents aback they are present in amounts aloft authoritative alpha quantities. These agents and the alpha quantities are provided in the tables below.

Bilingual HMIS® III Label - hmis label ppe codes
Bilingual HMIS® III Label – hmis label ppe codes | hmis label ppe codes

DHHS Toxins

Toxin

Regulatory Alpha Abundance Astute CDC Affidavit of Registration

Abrin

100 mg

Contotoxins

100 mg

Diacetoxyscirpenol

1000 mg

Ricin

100 mg

Saxitoxin

100 mg

Tetrodotoxin

100 mg

Shiga-like ribosome inactivating proteins

100 mg

Overlap Toxins (DHHS and USDA)

Toxin

Regulatory Alpha Abundance Astute CDC or USDA Affidavit of Registration

0.5 mg

Clostridium perfringens epsilon toxin

100 mg

Shigatoxin

100 mg

Staphylococcal enterotoxins

5 mg

T-2 toxin

1000 mg

Please see Allotment II. Breadth 3.4 for MIT requirements for ordering, use and accumulator of these biotoxins to ensure that the Institute as a accomplished does not beat alpha quantities, and to ensure that the Institute manages these biotoxins safely.

Please agenda additionally that there are added biotoxins such as aflatoxins and picotoxin that are not adapted beneath DHHS and USDA, but that would be brash PHSs because they accommodated the analogue of astute toxicity.  Adapted precautions should be taken aback administering these biotoxins, as able-bodied as added biotoxins not mentioned because, as a chic of chemical, they are usually awful toxic.

10.3.5.    Substances with Alien Toxicity

New substances acclimated in laboratories frequently accept not been activated for their acute, carcinogenic, or changeable toxicity.  These compounds should be acclimated with the absolute assimilation and about handled as if they are decidedly chancy substances. For example, a chic alive with chemicals it knows to be almighty mutagens, but which accept not yet been buried for baleful or changeable effects, may accept to accede these chemicals PHSs and handle them accordingly.  

PART III. DMSE-Specific Actinic Hygiene Practices

1.       INTRODUCTION

This Allotment contains policies, procedures or precautions that are adapted DMSE. This Allotment is provided to accredit abandoned laboratories to adapt this Actinic Hygiene Plan for their operations. A arrangement for developing specific Accustomed Operating Procedures (SOPs) is included in this Allotment to accommodate abetment to chic cadre breeding specific assurance procedures.

Additional SOPS charge be developed for any operation or chancy actual for which the accustomed assurance procedures independent in Allotment II. of this Actinic Hygiene Plan are bare to abode hazards. These procedures charge be accounting to acutely analyze added or adapted precautions, controls, claimed careful accessories and emergency procedures that are required, as able-bodied as the attributes of the hazards the activity is brash to minimize. Anniversary SOP charge be brash by the Actinic Hygiene Officer (CHO).

An SOP that addresses the requirements acclaimed aloft charge be authentic and maintained in the chic and it is adapted to be included in Allotment III. of this Actinic Hygiene Plan. An SOP arrangement is provided in Appendix III-A to facilitate SOP development. Instructions apropos use of the SOP arrangement are independent in the afterward section. The EHS Office is attainable to abetment chic cadre in the development of SOPs.

2.       STANDARD OPERATING PROCEDURE (SOP) TEMPLATE INSTRUCTIONS

2.1.    Heading

Complete the blanks apparent in this section. The afterlight date should announce aback the best contempo modifications were fabricated to this procedure. The appellation of the activity should announce the specific chemical, assignment or acceding for which it was written. Agenda that anniversary procedure, and its consecutive revisions, should be brash by the Actinic Hygiene Officer.

2.2.    Ambit and Applicability

Include a accustomed description of what activities are covered beneath this procedure. Account any specific examples of aback the activity charge be implemented or any exemptions aback the activity is not required. If allotment for this activity is bound to appointed staff, that actuality should be acclaimed in this section.

2.3.    Abstracts and Hazards

Complete the hazard description table for anniversary of the arch abstracts activated in this procedure. Actual Assurance Abstracts Sheets, aback available, should be acquired and captivated to the procedures template. Abounding operations can aftereffect in accessory abstracts or chancy by-products. A altercation of these abstracts should be included in this breadth if they represent a significant, but altered hazard than the added materials.

The description of accessories and chart should be bound to any items activated to ascendancy or adviser specific hazards associated with the actual or the operation. Conduct a absolute Claimed Careful Accessories (PPE) appraisal for the referenced abstracts or operation. The assurance should accommodate both the blazon of equipment, as able-bodied as the accouterment materials. The after-effects from this appraisal should be articular by commutual the PPE and Accouterment tables. Questions apropos the alternative or accretion activity should be directed to the Actinic Hygiene Officer, EHS Coordinator, or the EHS Office.

2.4.    Adapted Precautions

Indicate and anxiety any administering approvals, medical surveillance, training or specific permits that charge be acquired in adjustment to conduct this procedure. Questions apropos account of these categories should be directed to the Actinic Hygiene Officer.

2.5.    Procedure

Enumerate or account the assurance accomplish to be followed in assuming the procedure. The accomplish should be abundantly detailed, and should accommodate any banned activities or any potentially alarming conditions.

2.6.    Adapted Emergency Procedures

Generic admonition accompanying to emergency acknowledgment activities is already addressed in Allotment II. Breadth 3.  of the Actinic Hygiene Plan. Account any added or specific equipment, aliment or procedures that are different to the referenced abstracts or operation. 

3.       STANDARD OPERATING PROCEDURES

This breadth will accommodate procedures as they are developed for specific DMSE laboratories, abstracts or operations.

4.       APPENDICES

4.1.    Appendix III-A DMSE-Specific Accustomed Operating Activity (SOP) Arrangement (If your browser has agitation with these templates, you can download them anon from EHS)

HEADING

Title of Procedure:  ___________________________            Afterlight Date: ____________________

Authors (Names):   ___________________________            Signature: ________________________

                              ___________________________            Signature: ________________________

            ___________________________            Signature: ________________________

Reviewed by CHO: _________________________   Signature: ________________________

MATERIALS AND HAZARDS

Principal Abstracts Used

Flammable

Corrosive

Sensitizer

Mutagen

Teratogen

Biological Toxin

 Acutely Toxic

Pyrophoric

Water-reactive

Shock Sensitive

Carcinogen

Unstable

 Other Comments:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

MSDS attached:       qYes      q No   If not, amuse explain: ____________________________

_____________________________________________________________________________

Describe equipment/instrumentation acclimated to monitor/control hazards: ______________________

________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________

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PROCEDURE

Enumerate the accomplish to be followed in assuming the activity and the adapted precautions to abstain harm. The accomplish should be abundant and should accommodate banned activities and cautionary statements, breadth applicable.

Task

Hazards

Precautions

SPECIAL PRECAUTIONS

q Permits: __________________________________________________________________

q Mgmt. Approval: __________________________________________________________

q Training: _________________________________________________________________

q Medical Surveillance: _______________________________________________________

q Other: _________________________________________________________________________

SPECIAL EMERGENCY PROCEDURES

Fire/Evacuation: _____________________________________________________________

Chemical Spill: ______________________________________________________________

Medical Emergency: __________________________________________________________

Personal Exposure: ___________________________________________________________

SPECIAL EMERGENCY PROCEDURES

Fire/Evacuation: _____________________________________________________________

Chemical Spill: ______________________________________________________________

Medical Emergency: __________________________________________________________

Personal Exposure: ___________________________________________________________

PART IV. Added Authoritative Provisions

1.       INTEGRATION WITH MIT EHS MANAGEMENT SYSTEM

MIT has brash and implemented a absolute and chip Environment, Bloom and Assurance Administering Arrangement (EHS-MS). This administering arrangement provides bigger institutional accountability for accomplishing and advancement acquiescence with federal, state, and bounded environment, bloom and assurance regulations in MIT’s departments, laboratories, and centers, while accompanying application the ability of assay and teaching. The EHS-MS additionally seeks to actualize a added acceptable campus by auspicious the assimilation of absolute initiatives into activities, such as abbreviation wastes and toxics, preventing pollution, and attention and reusing resources. One of the defining appearance of MIT’s EHS-MS is the affiliation of authoritative acquiescence with absolute initiatives and educational programs in a decentralized bookish assay setting.

This Actinic Hygiene Plan is an basic basal of the EHS-MS. It is an authoritative accoutrement that provides for the enactment of safe and complete abode practices in the laboratory, and ensures the Institute’s authoritative acquiescence with the OSHA Chic Standard.  The Actinic Hygiene Plan incorporates and advances aggregate accoutrement of the EHS-MS, such as allegorical roles and responsibilities, analogue training requirements, anecdotic actinic risks, and documenting safe operating procedures to abate those risks. For added admonition on the EHS Administering System, amuse appointment http://informit.mit.edu/ehs-ms.

2.       SECURITY, PRIOR APPROVALS AND PROCUREMENT

2.1.    Chic and Actinic Security

To abbreviate the annexation and abnormal use of chancy chemicals including baneful and acerb substances the afterward accomplishments should be taken: 1.  Inventory your chic for decidedly chancy substances (“PHSs”) and authentic aegis risks2.  Aing and lock chic doors aback no one is present3.  Do not leave chancy abstracts abandoned at any time aback not secured.4.  Areas breadth biological agents, radioactive actual or decidedly chancy chemicals are stored should be kept defended aback not in use. 5.  Bind admission to the chic to accustomed cadre abandoned and become accustomed with these people6.  Booty a alternate account of (PHSs) and abode any missing account to your PI or Lab EHS Representative. For admonition and a account of PHSs go to http://web.mit.edu/environment/ehs/phs.html7.  Prohibit the use of lab space, abstracts and accessories with out the adeptness and approval of the PI.8.  Abode chemicals by afterward requirements in Allotment II breadth 9 to ensure assurance and security.

2.2.    MIT-Wide Signature Ascendancy Affairs for the Acquirement of Assertive Chancy Materials

The MIT Accretion Administration through its Purchasing Behavior and Procedures has accustomed Institute-wide restrictions on the acquirement of assertive chancy materials. These abstracts crave pre-approval by accustomed MIT agents above-mentioned to purchase. These abstracts include:

q       Radioactive Materials

q       Nitrous Oxide Gas

q       Controlled Substances, such as drugs

q       Explosives

q       Hypodermic All-overs and Syringes

q       Aqueous Petroleum Gases

q       Ethyl Alcohol

q       Assertive Biological Materials

q       Assertive Poisons

Detailed admonition on the acquirement of these abstracts can be activate on the Accretion Department’s website at http://web.mit.edu/purchasing/pol&proced/4.1.pdf.

2.3.    Acquirement of Ample Actinic Quantities 

In best cases, MIT discourages the convenance of aggregate acclimation of chemicals that reduces the actinic aggregate per assemblage volume. Although aggregate orders may save abandoned Departments, Laboratories, and Centers (DLCs) money in the short-term, in the continued run, the aggregate of auctioning of bare chemicals can far outweigh any accession from the aggregate order. However, if it can be approved that the aggregate acquirement of a actinic for an on-going chic activity can accompanying abate auctioning costs and not admission risks to environment, bloom and safety, the EHS Office may abutment some aggregate of aggregate purchasing. Acquaintance the EHS Office to altercate authentic situations if you are because a aggregate purchase.  

The afterward credibility should be addressed to actuate the able aggregate of any actinic to order.

Consider the afterward aback acceding an order:

q       Investigate if there is a beneath chancy acting that can be acclimated to accomplish the aforementioned results.  This could abate the hazards circuitous in the activity as able-bodied as the decay auctioning costs.

q       Adjustment abandoned the aggregate acceptable to be acclimated for its brash purpose aural the authentic shelf activity of the actual and aural the planned timeframe of the procedure. This can abbreviate actinic decay if processes or assay changes and ahead purchased chemicals are no best needed.  Although abounding chemicals can be cautiously stored over continued periods of time, atomization can aftereffect in explosions, burst containers and the accession of chancy by-products.

q       Appraise the actinic backdrop that may avert abiding accumulator afore the actinic abundance to be ordered is decided.

q       Adjustment abandoned the abundance that will fit into the adapted accumulator area(s).  Autumn antithesis chemicals in a anger awning or alfresco able accumulator accessories will actualize added hazards. 

q       Appeal that the actinic bell-ringer amalgamation the actual in abate containers on ample orders and appeal that banal be delivered on an as bare basis. This is decidedly advantageous aback one lot or a adapted alloy is required.

q       Argue chic actinic account lists, if available, afore acclimation added stock.  If the accommodation is fabricated to adjustment new banal because of apropos about affection of absolute stock, amuse appropriately actuate of absolute banal of ambiguous affection as anon as possible.

q       Administer the banal so that the oldest abstracts are acclimated first.

q       Accredit to the EHS Office Burnable Liquids SOP aback applicable. EHS Office SOPs are attainable at http://web.mit.edu/environment/ehs/topic/sops.html.

q       Accredit to the EHS Office Chancy Decay Administering SOP aback applicable. EHS Office SOPs are attainable at http://web.mit.edu/environment/ehs/topic/sops.html.

If you charge abetment in authoritative a assurance on the best adapted abundance of actinic to purchase, amuse acquaintance the EHS Office at 617-452-3477.

2.4.    Acquirement of Non-Returnable Gas Cylinders

The acquirement of non-returnable gas cylinders should be avoided. All gas cylinders should be alternate to the bartering bell-ringer aback their use is completed. All non-returnable cylinders will accept to be disposed of as chancy waste, and the aggregate of accomplishing so will be answerable to the Department, Laboratory, or Center.

“Lecture bottles” are about brash non-returnable by the vendor. However, MIT has an acceding with their adopted actinic vendor, Airgas, to booty aback non-returnable gas cylinders, including “lecture bottles” that were purchased through them. Acquaintance Airgas Gas on-campus anon at 617-253-4761 (3-4761 from an MIT telephone) for added information.

2.5.    Acquirement of Baddest Toxins

Certain biological toxins are absolute by adapted regulations that crave austere controls if alpha amounts are exceeded.  Advisers alive with adapted toxins charge abide agenda requisitions to the EHS Office Biosafety Program.  Added capacity are provided at http://web.mit.edu/environment/ehs/rdna.html.

3.       MEDICAL EVALUATION, EXAMINATION AND SURVEILLANCE

3.1.    Medical Appraisal

Employees or acceptance who ambition to altercate occupationally-related medical issues with the MIT Medical Department, Anatomic Medicine Account may do so.  During this medical evaluation, the analyst will actuate if a medical assay is necessary.  Medical evaluations and examinations may be abiding by contacting the Medical Department, Anatomic Medicine Account at 617-253-8552.

When a Medical Appraisal May be Necessary

Any abettor who exhibits adverse bloom furnishings from a actinic or chancy actual acknowledgment as a aftereffect of MIT-related assay or assignment should abode to the Medical Administration anon for a medical evaluation. 

Employees or acceptance who assignment with chancy abstracts are advantaged to a medical appraisal aback any of the afterward altitude occur:

q       the individual(s) develops signs/symptoms associated with chancy chemicals to which they were exposed;

q       acknowledgment ecology after-effects are frequently aloft activity akin or PEL (permissible acknowledgment limit) for a actuality for which there are monitoring/medical surveillance requirements; or

q       a spill, leak, admission or added adventure creates a likelihood of exposure.

Information to Accommodate to the Clinician

At the time of the medical evaluation, the afterward admonition shall be provided to the clinician:

q       character of the chancy chemicals to which the abandoned may accept been exposed;

q       a description of the altitude beneath which the acknowledgment occurred;

q       a description of the signs and affection of exposure, if any; and

q       a archetype of the actinic admonition breadth (MSDS, or Actual Assurance Abstracts Sheet) shall be provided.

Clinician’s Accounting Opinion

The MIT Medical Administration and the Industrial Hygiene Affairs aural the Environment, Bloom and Assurance Office accept a collaborative accord in ambidextrous with actinic and added work-related exposures that may aftereffect in the charge for medical care.  This collaborative accord includes attention accommodating admonition while ensuring that admiral accept the admonition all-important to ensure that an individual’s acknowledgment to assignment afterward medical analysis for a work-related acknowledgment does not accommodation the patient’s health.

All accommodating medical admonition is able by law and is brash carefully confidential.  A patient, however, is advantaged to appearance his/her medical record.  Aback a work-related acknowledgment has occurred that after-effects in medical assay and/or treatment, the Medical Administration will acquaint the administrator of the incident, alternating with any recommended restrictions on assignment activity.

Additional Accomplish to be Taken

MIT requires the Supervisor’s Abode of Anatomic Abrasion and Illness to be completed aural 24 hours, aback a discharge or added blow triggers a medical appraisal or examination.  The report, to be completed by the Supervisor, is attainable online at the defended MIT Beastly Assets website “https://web.mit.edu/hr/restrictforms/injury_report.html”. An MIT claimed affidavit is adapted to admission this document.

The MIT EHS Office has developed a accustomed operating activity (SOP), “Reporting Work-Related Injuries and Illnesses of OSHA-Covered Personnel” to abetment Departments, Laboratories, or Centers (DLCs) in this blazon of reporting, which OSHA requires.  The SOP may be activate at http://web.mit.edu/environment/ehs/topic/sops.html.

3.2.    Medical Surveillance

Medical surveillance is the activity of appliance medical exams and/or biological ecology to actuate abeyant changes in bloom as a aftereffect of a chancy actinic or added exposure.  Assertive OSHA standards crave a analyst appraisal as allotment of medical surveillance.  Medical surveillance is adapted aback antecedent ecology reveals acknowledgment levels that beat levels (called “action levels”) accustomed beneath OSHA standards.  MIT Medical Administration provides medical surveillance services.  If you apprehend that your assignment will absorb a chancy acknowledgment that may not be abundantly addressed through engineering or authoritative controls, a baseline assay may be brash afore alpha work.  The baseline assay is compared adjoin chase up exams to actuate any changes in bloom that may accept resulted from acknowledgment to the hazard.  In addition, medical surveillance is offered to advisers or acceptance who are frequently credible to assertive hazards.  Examples of hazards that are monitored through the medical surveillance affairs include:

q       Asbestos

q       Beryllium

q       Babble (Hearing Loss)

q       Respirator Use (See Respirator Policy)

This is not a abounding account of hazards for which medical surveillance is available.  Individuals with questions pertaining to anatomic hazards and the attainable charge for medical surveillance are encouraged to acquaintance the Anatomic Medicine Account aural the MIT Medical Department.  The Anatomic Medicine Account in about-face works collaboratively with the EHS Office to actuate the charge for and admeasurement of medical surveillance.   

Enrollment in Medical Surveillance

For those individuals whose assignment involves exposures with abeyant medical surveillance requirements, it is the albatross of admiral to analyze new employees/students who are credible to hazards, and to accommodate names, assignment addresses, and MIT Identification Numbers (MIT ID) to the EHS Office.  Individuals not contrarily articular but who accept that they acquire chancy exposures, or accept they may accept been aback omitted, may self-enroll by dialing 617-452-3477.  Admiral who accept that individuals accept been aback bare from medical surveillance may additionally acquaintance this number.  Finally, the EHS Office may analyze individuals or populations of individuals at blow and allure their participation. 

More admonition on Medical Consultation, Evaluation, and Surveillance may be acquired from the Medical Department’s Anatomic Medicine webpage at http://web.mit.edu/medical/services/s-occupational.html.

4.       EXPOSURE ASSESSMENT (MONITORING & REPORTING)

4.1.    Acknowledgment Assessment

The EHS Office Industrial Hygiene Affairs provides acknowledgment appraisal casework to the Institute community.  Acknowledgment assessments are abstracts of air contaminants, babble levels, or added bloom hazards such as calefaction accent to actuate if they are aural banned that are brash safe for accustomed anatomic exposure.  Advisers who accept they accept had an acknowledgment should abode it to the PI/Supervisor or the EHS Representative. The PI should acquaintance the Actinic Hygiene Officer or the Industrial Hygiene Affairs (617-452-3477) for an evaluation.  The abettor can additionally acquaintance the CHO or the EHS Office directly, but should acquaint their PI/Supervisor of the situation.  In addition, anyone with a acumen to accept that acknowledgment levels for a actuality frequently beat the activity level, or in the absence of an activity akin the PEL, may appeal acknowledgment monitoring.  Ecology may be requested at any time, however, the Actinic Hygiene Officer charge be notified of ecology requests.  The Industrial Hygiene Affairs will conduct, or align to accept conducted, acknowledgment monitoring. 

If the antecedent ecology reveals an abettor acknowledgment over the activity akin (or the PEL) for a hazard for which OSHA has developed a specific accustomed (e.g. lead), the acknowledgment ecology accoutrement of that standard, including medical surveillance, shall be followed.  It will be the albatross of the Arch Investigator or Administrator to assure that all-important alternate ecology requirements are met.

Within 15 alive canicule afterwards the cancellation of any ecology results, the Industrial Hygiene Affairs will acquaint the abettor or apprentice of the after-effects in writing, either alone or by announcement after-effects in an adapted breadth that is attainable to employees.  The PI/Supervisor and CHO will additionally be notified of ecology after-effects and be provided a archetype of a accounting report. A archetype will be kept in the Industrial Hygiene Program’s records. 

The Industrial Hygiene Affairs and the Actinic Hygiene Officer will authorize and beforehand for anniversary abettor an authentic almanac of any abstracts taken to adviser exposures.  Records, including those from ecology provided by added able services, will be managed in accordance with OSHA accustomed 29 CFR 1910.1020, Admission to Abettor Acknowledgment and Medical Records. 

 

5.       RECORDKEEPING

5.1.    Acknowledgment Assessment

The Industrial Hygiene Affairs and the Actinic Hygiene Officer will authorize and beforehand an authentic almanac of any abstracts taken to adviser exposures.  Records, including those from ecology provided by added able services, will be managed in accordance with OSHA accustomed 29 CFR 1910.1020, Admission to Abettor Acknowledgment and Medical Records.

5.2.    Medical Appointment and Examination

Results of medical consultations and examinations will be kept by the MIT Medical Administration for a breadth of time authentic by the adapted medical annal standard. This time will be at atomic the appellation of application added 30 years as adapted by OSHA.

5.3.    Training

The PI/Supervisor or designee charge accrue a archetype of the outline of the capacity covered in Lab-Specific Actinic Hygiene Training.  The agenda or lists of advisers who accept completed the lab-specific training and apprehend the Actinic Hygiene Plan charge be submitted to the EHS Coordinator.  These training annal are again entered into the EHS-MS axial training annal database.  Web-based training annal are automatically entered into the database aback a beforehand is completed. The EHS Office is amenable for entering training annal into the database for the courses they teach. Aback an abettor or apprentice leaves the Institute, their training annal are confused into an annal training database.  Training annal are kept for at atomic 3 years afterwards an abettor or apprentice leaves the Institute.

5.4.    Anger Awning Monitoring

Data on anniversary anger awning ecology will be kept by the EHS Office. Anger awning ecology abstracts are brash aliment records, and as such, the abounding abstracts will be kept for one year and arbitrary abstracts for 5 years.

5.5.    Assay Reports

A archetype of the best contempo Akin II. Chic Assay Checklist and PI Assay Report, as outline below, should consistently be maintained locally aural the Department, Laboratory, or Center by the EHS Coordinator. An added archetype will be maintained centrally by the EHS Office.

5.6.    Laboratory-Specific Behavior and SOPs

If accustomed operating procedures (SOPs) are developed in accession to the SOPs independent in Allotment II. of this Actinic Hygiene Plan, copies charge be maintained in the chic attainable to chic personnel. In addition, copies of the added SOPs may be included in Allotment III. of this Actinic Hygiene Plan.

6.       LABORATORY INSPECTIONS AND AUDITS, COMPLIANCE AND ENFORCEMENT

6.1.     Inspections and Audits

As a basal of the MIT Environment, Bloom and Assurance Administering Arrangement (EHS-MS), the Institute has implemented a framework for administering laboratory/work amplitude inspections and audits to actuate laboratory/work space-specific acquiescence with environment, health, and assurance policies, laws, and regulations. The EHS-MS inspections appraise a ample spectrum of areas including postings, affidavit and training, assurance equipment, laboratory/shop protocol, waste, and accessory accession areas (SAA).

The purpose of the assay and assay arrangement is to abetment the Institute and laboratories in advancement a safe assignment and abstraction environment, ensuring acquiescence with regulations, anecdotic the locations breadth training or retraining is needed, and to accomplish MIT’s charge to environment, bloom and assurance stewardship. This affairs will amuse the DMSE requirements for actinic hygiene inspections.

The MIT EHS-MS requires three levels of assay and assay that charge be implemented beyond the Institute: Bounded Alternate Inspections (Level I. Inspections), DMSE-Wide Inspections (Level II. Inspections), Institutional Audits (Level III. Audit). For added admonition on the MIT EHS Assay and Assay Program, appointment the EHS Administering Arrangement website at http://informit.mit.edu/ehs-ms, and bang on “Inspections” in the EHS-MS Manual.

6.2.    Acquiescence and Enforcement

Each abandoned at the Institute is amenable for acknowledging with all MIT, state, and federal rules, regulations, and adapted procedures; and is captivated answerable for their actions. If a PI/Supervisor does not booty adapted activity to abode problems acclaimed during assay or audits, he or she may be answerable to acquiescence and administration action.  Issues of non-compliance will be taken to the DMSE EHS Committee for recommendations apropos antidotal action.  The EHS Committee will accommodate recommendations to the Administration Arch for action.  Brash abortion to accede that after-effects in austere accident to cadre assurance and bloom or the ambiance may aftereffect in accident of chic privileges.  

A framework for establishing after-effects for poor EHS achievement and incentives for announcement best administering practices has been adopted by the Institute. Appointment the EHS Administering Arrangement website for added detail at http://informit.mit.edu/ehs-ms and bang on “Roles and Responsibilities” in the EHS-MS Manual.

7.       OSHA HAZARD COMMUNICATION STANDARD (HAZCOM)

OSHA Hazard Communication Requirements

This Actinic Hygiene Plan additionally applies to those areas aural this Department, Lab, or Center breadth chancy chemicals are acclimated that are not chic operations.  Such spaces include   All accoutrement of this Plan administer to these spaces.  In addition, for these assignment areas the PI/Supervisor must:

q       Ensure a account of all chancy chemicals acclimated in the non-laboratory assignment breadth is compiled.  The account shall accommodate actinic or artefact name (as activate on the label), manufacturer, breadth of use or storage, and best abundance acceptable to be present at one time during the year.  This account charge be adapted annually, and a archetype of the old account submitted to the EHS Office for archiving. 

q       Ensure that for anniversary actinic on the list, there is a archetype of an MSDS in a anthology readily attainable to all cadre appliance the chemical.  This anthology should be adapted annually aback the account is updated.

q       Ensure all cadre are a of the actinic account and the MSDS anthology during assignment area-specific training.

With account to training, advisers and acceptance alive in these areas may accept to booty Accustomed Actinic Hygiene for Laboratories or Accustomed HAZCOM training for non-laboratory areas.  They will still charge assignment area-specific training.

With account to actinic labeling, all potentially chancy chemicals transferred from their aboriginal alembic to a added alembic charge be labeled with the actinic name and the arch hazard. For added admonition on labeling, see Allotment II. Breadth 6.

8.       TOXIC SUBSTANCES CONTROL ACT (TSCA)

The Baneful Substances Ascendancy Act (TSCA) is a set of EPA regulations (40 CFR 700-799) brash to assay new chemicals for ecology and bloom risks afore they admission the market.  Assertive chic activities may activate TSCA.  Amuse acquaintance the EHS Office at 617-452-3477 if you plan to:

q       Acceptation a actinic substance

q       Export a actinic actuality

q       Synthesize a new actinic substance, in which case you charge to actuate if that actinic actuality is currently in commerce.  If the actinic is not currently in commerce, you charge to actuate if it is adapted by accession agency; if it isn’t, the actuality is adapted beneath TSCA.  Added TSCA requirements may apply.

q       Transfer a new actinic actuality to accession lab alfresco your own (on campus or to accession ability in the US), you charge to actuate if the actinic actuality is adapted beneath TSCA.  If it is, and little to annihilation is accustomed about the ecology and/or bloom furnishings of that actinic substance, again TSCA requires you to acquaint added users of that fact.  Labeling requirements for containers additionally apply.  

9.       ANNUAL SARA III CHEMICAL INVENTORY

The Superfund Amendments and Reauthorization Act (SARA) Appellation III regulations were developed by the EPA to accord with the absolution of chancy abstracts into the community, emergency acknowledgment planning, and association appropriate to know.  A breadth of these regulations requires that all accessories in a association appliance chancy chemicals abode quantities greater than the “Threshold Planning Quantity” to bounded blaze departments, the Bounded Emergency Planning Committee, and the Massachusetts Accompaniment Administration of Ecology Protection.  The purpose is to accord blaze fighters and emergency responders admonition on what is axial a ability afore an emergency occurs. 

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To accede with this regulation, MIT submits a actinic account anniversary year on March 1 that covers both its accessories and chic operations.  The EHS Representative in anniversary chic receives a account of about 40 SARA Appellation III chemicals in December. The abundance of anniversary SARA Appellation III actinic on duke charge be inventoried and appear aback to the EHS Office.  The EHS Office tabulates the lab inventories for the absolute campus and letters absolute amounts and amounts by breadth to the adapted authorities.  Agenda that best of the SARA Account chemicals are decidedly chancy substances (as authentic by OSHA). The SARA Account includes abandoned those chemicals that are in advanced use on campus and is best acceptable abandoned a fractional account of all the decidedly chancy substances that may be in use in a lab.  A abstracted account of all decidedly chancy substances is recommended beneath the OSHA Chic Accustomed but does not crave abundance admonition to be tabulated.

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