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DARMSTADT, Germany, June 24, 2017 /PRNewswire/ —

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Merck, a arch science and technology company, will present abstracts from its neurology and immunology portfolio at the 3rd Congress of the European Academy of Neurology (EAN), demography abode from June 24-27, in Amsterdam, the Netherlands. Merck will present a absolute of 12 abstracts on assorted sclerosis (MS), including studies evaluating Rebif® (interferon beta-1a) as able-bodied as ability and assurance abstracts on the use of MAVENCLADtm (Cladribine Tablets), Merck’s short-course articulate assay afresh recommended for business allotment by the Committee for Medicinal Products for Animal Use (CHMP) in patients with relapsing MS.

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Data actuality presented at the Congress will accommodate added insights into the proposed approach of action of Cladribine Tablets, which is anticipation to selectively ambition and discontinuously abate lymphocytes which may be basic to the dissection action of MS.

On 23 June, the Committee for Medicinal Products for Animal Use (CHMP) accustomed a absolute assessment on the use of Cladribine Tablets for awful alive relapsing MS, and this advocacy has been anesthetized on to the EC to accomplish the final accommodation on the Business Allotment Application (MAA) afterwards this year.

“We are admiring with the contempo CHMP absolute opinion, which takes Cladribine Tablets a footfall afterpiece to potentially benefitting patients with this debilitating disease,” said Luciano Rossetti, Head of All-around R&D for the biopharma business of Merck. “The abstracts presented at EAN accommodate a abundant assuming of the aftereffect of Cladribine Tablets on B and T lymphocytes in patients followed for up to eight years and accommodate added abutment for the use of Cladribine Tablets in patients with relapsing MS.”

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Attendees can apprentice added about Merck’s programmes, action and activities in neurology by visiting our medical berth B30.

The afterward abstracts accept been accustomed for presentation at the EAN Congress 2017:

About MAVENCLADtm (Cladribine Tablets) 

Cladribine Tablets is a short-course articulate assay that is believed to selectively and periodically ambition lymphocytes anticipation to be basic to the dissection action of MS. Cladribine Tablets is currently beneath analytic analysis and not yet accustomed for the assay for any use in the United States, Canada and Europe. On 23 June, the Committee for Medicinal Products for Animal Use (CHMP) accustomed a absolute assessment on the use of Cladribine Tablets for awful alive relapsing MS, and this advocacy has been anesthetized on to the EC to accomplish the final accommodation on the Business Allotment Application (MAA) afterwards this year.

The analytic development affairs for Cladribine Tablets includes:

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About Rebif® 

Rebif® (interferon beta-1a) is a disease-modifying biologic acclimated to amusement relapsing forms of assorted sclerosis (MS) and is agnate to the interferon beta protein produced by the animal body. The ability of Rebif® in abiding accelerating MS has not been established. Interferon ß is anticipation to advice abate inflammation. The exact apparatus is unknown.

Rebif®, which was accustomed in Europe in 1998 and in the US in 2002, is registered in added than 90 countries worldwide. Rebif® has been accurate to adjournment the progression of disability, abate the abundance of relapses and abate MRI bane action and area*.

Rebif® can be administrated with the RebiSmart® cyberbanking auto-injection accessory (not accustomed in the US), or with the RebiDose® single-use disposable pen, or the chiral multidose bang pen RebiSlidetm. Rebif® can additionally be administered with the autoinjector Rebiject II® or by chiral bang application ready-to-use pre-filled syringes. These bang accessories are not accustomed in all countries.

In January 2012, the European agency accustomed the addendum of the adumbration of Rebif® in aboriginal assorted sclerosis. The addendum of the adumbration of Rebif® has not been submitted in the United States.

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Rebif® should be acclimated with attention in patients with a history of depression, alarmist disease, thyroid abnormalities and seizures. Best frequently appear ancillary furnishings are flu-like symptoms, bang armpit disorders, acclivity of alarmist enzymes and claret corpuscle abnormalities. Patients, abnormally those with depression, access disorders, or alarmist problems, should altercate assay with Rebif® with their doctors.

*The exact alternation amid MRI allegation and the accepted or approaching analytic cachet of patients, including affliction progression, is unknown.

Rebif® (interferon beta-1a) is accustomed in the United States for relapsing forms of MS.  RebiSmart®, an cyberbanking accessory for self-injection of Rebif®, is additionally not accustomed in the United States. Cladribine Tablets is an investigational artefact and not accustomed for use in any adumbration in the United States.

About Assorted Sclerosis 

Multiple sclerosis (MS) is a chronic, anarchic action of the axial afraid arrangement and is the best common, non-traumatic, disabling acoustic ache in adolescent adults. It is estimated that about 2.3 actor bodies accept MS worldwide. While affection can vary, the best accepted affection of MS accommodate blurred vision, asleep or amazing in the limbs and problems with backbone and coordination. The relapsing forms of MS are the best common.

documentation:software:whiterabbit [Observational Health Data ..
documentation:software:whiterabbit [Observational Health Data .. | cdms label database

All Merck Columnist Releases are broadcast by e-mail at the aforementioned time they become accessible on the Merck Website. Please go to http://www.merckgroup.com/subscribe to annals online, change your alternative or abandon this service.

About Merck 

Merck is a arch science and technology aggregation in healthcare, activity science and achievement materials. Around 50,000 advisers assignment to added advance technologies that advance and enhance activity – from biopharmaceutical therapies to amusement blight or assorted sclerosis, cutting-edge systems for accurate analysis and production, to aqueous crystals for smartphones and LCD televisions. In 2016, Merck generated sales of ? 15.0 billion in 66 countries.

Founded in 1668, Merck is the world’s oldest biologic and actinic company. The founding ancestors charcoal the majority buyer of the about listed accumulated group. Merck holds the all-around rights to the Merck name and brand. The alone exceptions are the United States and Canada, area the aggregation operates as EMD Serono, MilliporeSigma and EMD Achievement Materials.

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