Immunomedics, Inc., a biopharmaceutical aggregation primarily focused on the development of monoclonal antibody-based articles for the targeted analysis of cancer, autoimmune and added austere diseases, has accustomed a key US apparent no. 8,617,558 for added claims beneath the apparent ancestors “Camptothecin-binding atom conjugates,” and US apparent no. 8,617,518 with added claims for the apparent ancestors “Methods and compositions for bigger F-18 labeling of proteins, peptides and added molecules.”
Patent 8,617,558 relates to our proprietary linker technology for conjugating SN-38 to the Company’s humanized antibodies for targeted commitment of the almighty biologic to the tumour. The apparent will expire in December 2023. Added patents accoutrement the Company’s antibody-drug conjugates are actuality prosecuted in above countries worldwide.
“This is a key apparent for the aegis of our antibody-drug conjugates apparent family, of which IMMU-132, an anti-TROP-2-SN-38 conjugate, and IMMU-130, an anti-CEACAM5-SN-38 conjugate, aggregate two of our best agitative new agents for solid blight therapy,” commented Cynthia L Sullivan, admiral and arch controlling officer. “Both IMMU-132 and 130 are in appearance II analytic development and we plan to address after-effects from these studies in the additional division of 2014 at accessible accurate and medical conferences.”
In aboriginal dose-escalation studies, the two antibody-SN-38 conjugates accept apparent affirmation of tumour abbreviating in patients with difficult-to-treat solid tumors who had bootless assorted above-mentioned therapies, including irinotecan.
SN-38 is the alive metaite of irinotecan, a camptothecin alternation accustomed for the analysis of metastatic colorectal cancer. While SN-38 is 2 to 3 orders of consequence added almighty than its ancestor molecule, it does not deliquesce in baptize and cannot be administered anon to patients. Our different linker allows us to aftermath antibody-SN-38 conjugates that are acrid in baptize with accomplished yields, as able-bodied as canning of antibiotic bounden and biologic activity, alike afterwards adhering about seven biologic molecules per antibody. The additional patent, 8,617,518, which will expire in December 2027, apropos the methods and compositions of labeling peptides and added molecules with the analytic radioisotope, fluorine-18 (F-18) or the alluring resonance imaging (MRI) label, fluorine-19 (F-19).
The Aggregation has invented a simple-to-use kit for the accelerated labeling of peptides and proteins, including antibodies, to be acclimated as imaging agents for positron-emission tomography (PET) and MRI of diseases. In particular, antibody-based targeting agents, an area of our strength, for immunoPET imaging can become a accompaniment analytic to our ameliorative products, including the antibody-drug conjugates currently in analytic trials.
“This is an important technology for us,” Sullivan stated, “and is of absorption to above biologic companies absent an imaging accompaniment to their therapeutics.”
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